Steve Saklad
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Steve Saklad
@saklad.name
320 followers 310 following 950 posts
Clin Prof Emeritus at UT Austin, Col of Pharm, Div of PTherapy & Trans Sci, based in San Antonio.

PharmD, BCPP, AAPP, clin care, CNS disorders & treatment, consultant for clin care & research, tech, space, equality, diversity, climate, & civility.
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Here are the modeled effects of delaying Hep B vaccinations from <https://www.medrxiv.org/content/10.1101/2025.11.24.25340907v1> cited by SciAm above. The alt text contains the actual text from the Results section of the abstract.
Results All delayed vaccination scenarios resulted in more infections, worse health outcomes, and higher costs than the current universal birth dose recommendation. Under perfect adherence, delaying HepB vaccination by 2 months for infants of HBsAg-negative parents led to an additional 90 acute infections, 75 chronic infections, 29 HBV-related deaths, with $16.4 million in added costs for infants born during one year. Delaying to 12 years resulted in an additional 190 acute infections, 50 deaths, and nearly $30 million in added costs. Delaying HepB vaccination to 12 years for infants of both HBsAg-negative and HBsAg-unknown parents resulted in an additional 2,351 acute infections, 744 deaths, and $368 million in excess costs. Imperfect adherence to the vaccination schedule amplified all negative outcomes substantially. Incorporating pre-vaccination serologic screening for delayed schedules markedly increased total costs.
December 2, 2025 at 11:27 PM