Sai Koukuntla
@saikoukunt.bsky.social
PhD Candidate @ JHU BME developing models for brain-wide neural dynamics | Advised by Adam Charles, Carlos Brody, and Tim Harris
Reposted by Sai Koukuntla
Y’all are reading this paper in the wrong way.
We love to trash dominant hypothesis, but we need to look for evidence against the manifold hypothesis elsewhere:
This elegant work doesn't show neural dynamics are high D, nor that we should stop using PCA
It’s quite the opposite!
(thread)
We love to trash dominant hypothesis, but we need to look for evidence against the manifold hypothesis elsewhere:
This elegant work doesn't show neural dynamics are high D, nor that we should stop using PCA
It’s quite the opposite!
(thread)
“Our findings challenge the conventional focus on low-dimensional coding subspaces as a sufficient framework for understanding neural computations, demonstrating that dimensions previously considered task-irrelevant and accounting for little variance can have a critical role in driving behavior.”
Neural dynamics outside task-coding dimensions drive decision trajectories through transient amplification
Most behaviors involve neural dynamics in high-dimensional activity spaces. A common approach is to extract dimensions that capture task-related variability, such as those separating stimuli or choice...
www.biorxiv.org
November 25, 2025 at 4:16 PM
Y’all are reading this paper in the wrong way.
We love to trash dominant hypothesis, but we need to look for evidence against the manifold hypothesis elsewhere:
This elegant work doesn't show neural dynamics are high D, nor that we should stop using PCA
It’s quite the opposite!
(thread)
We love to trash dominant hypothesis, but we need to look for evidence against the manifold hypothesis elsewhere:
This elegant work doesn't show neural dynamics are high D, nor that we should stop using PCA
It’s quite the opposite!
(thread)
Reposted by Sai Koukuntla
U.S. Public Research Benefits is a searchable repository that showcases the value of basic science in an easy and accessible format. @baselesspursuit.bsky.social shares how he and his colleagues developed the resource.
#neuroskyence
www.thetransmitter.org/science-and-...
#neuroskyence
www.thetransmitter.org/science-and-...
Our searchable repository of useful research can restore trust in federally funded basic science
Called U.S. Public Research Benefits, the database showcases the value of basic science in an easy and accessible format.
www.thetransmitter.org
November 5, 2025 at 2:50 PM
U.S. Public Research Benefits is a searchable repository that showcases the value of basic science in an easy and accessible format. @baselesspursuit.bsky.social shares how he and his colleagues developed the resource.
#neuroskyence
www.thetransmitter.org/science-and-...
#neuroskyence
www.thetransmitter.org/science-and-...
Reposted by Sai Koukuntla
SLAy-ing oversplitting errors in high-density electrophysiology spike sorting https://www.biorxiv.org/content/10.1101/2025.06.20.660590v1
June 25, 2025 at 9:15 PM
SLAy-ing oversplitting errors in high-density electrophysiology spike sorting https://www.biorxiv.org/content/10.1101/2025.06.20.660590v1