Pabi Sahoo
@sahoolab.bsky.social
Assistant Professor at Rutgers University | Molecular Neurobiologist | Neural Repair | Neurodevelopment
Very exciting results from the Fanzilber lab!
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are
induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
www.cell.com
May 16, 2025 at 3:52 PM
Very exciting results from the Fanzilber lab!
Reposted by Pabi Sahoo
ATP - not only a fuel source! Intriguing work from Marco Terenzio and colleagues at the OIST
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons
The protective role of ATP in neurons reduces protein aggregation and neurodegeneration.
www.science.org
April 26, 2025 at 7:22 PM
ATP - not only a fuel source! Intriguing work from Marco Terenzio and colleagues at the OIST
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Excellent story from the Woolf lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration - Nature Communications
Therapeutic interventions for motor axon regeneration following peripheral nerve injury are currently unavailable. Here authors show local administration of a non-muscle myosin II inhibitor at the inj...
www.nature.com
March 30, 2025 at 11:16 PM
Excellent story from the Woolf lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pretty cool!
“In neurons, RiboExM revealed a functional dichotomy between monosomes and polysomes. Monosomes were enriched in distal neurites at baseline, whereas polysomes formed dynamically in response to external stimuli…”
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...
www.science.org
March 7, 2025 at 9:29 PM
Pretty cool!
Reposted by Pabi Sahoo
New preprint from Roz Segal’s group on specialization in local axonal translation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Profiling local translatomes and RNA binding proteins of somatosensory neurons reveals specializations of individual axons
Individual neurons have one or more axons that often extend long distances and traverse multiple microenvironments. However, it is not known how the composition of individual axons is established or l...
www.biorxiv.org
March 3, 2025 at 3:18 PM
New preprint from Roz Segal’s group on specialization in local axonal translation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration | PNAS
Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2
in Caenorhabditis elegans, increases the growth of spontaneous...
www.pnas.org
February 28, 2025 at 2:16 PM
Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
First peer reviewed article from our lab is now out. If you are new to stress granule field, you will find this manuscript helpful. Big shout out to @Meghal Desai @keyagulati @Manasi Agrawal, @Shruti Ghumra Thanks @MerkinPnnrCtr for funding 🙏🏼
journals.lww.com/nrronline/ab...
journals.lww.com/nrronline/ab...
Stress granules: guardians of cellular health and triggers... : Neural Regeneration Research
play a critical role in minimizing cellular damage during stress. Composed of heterogeneous ribonucleoprotein complexes, stress granules are enriched not only in mRNAs but also in noncoding RNAs and v...
journals.lww.com
February 25, 2025 at 2:32 PM
First peer reviewed article from our lab is now out. If you are new to stress granule field, you will find this manuscript helpful. Big shout out to @Meghal Desai @keyagulati @Manasi Agrawal, @Shruti Ghumra Thanks @MerkinPnnrCtr for funding 🙏🏼
journals.lww.com/nrronline/ab...
journals.lww.com/nrronline/ab...
New study from the Twiss lab!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration
The small GTPase CDC42 promotes axon growth through actin filament polymerization and this growth is driven by axonal localization of the mRNA encoding the prenylated CDC42 isoform ( Prenyl-Cdc42 ). H...
www.biorxiv.org
February 11, 2025 at 10:28 PM
New study from the Twiss lab!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic biomolecular condensates enhance translation from a target mRNA in living cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synthetic biomolecular condensates enhance translation from a target mRNA in living cells - Nature Chemistry
Formation of biomolecular condensates composed of proteins and RNA facilitates the regulation of gene expression by modulating translation or facilitating RNA processing. Now, synthetic ribonucleoprot...
www.nature.com
February 10, 2025 at 6:56 PM
Synthetic biomolecular condensates enhance translation from a target mRNA in living cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration: Cell Reports www.cell.com/cell-reports...
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration
Boraas et al. identify that mRNAs and the stress granule RNA-binding protein G3BP1
form ribonucleoprotein (RNP) complexes at FAs. These RNPs regulate FA protein mobility
and cell migration under norma...
www.cell.com
February 1, 2025 at 3:15 PM
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration: Cell Reports www.cell.com/cell-reports...
Molecular determinants of condensate composition: Molecular Cell www.cell.com/molecular-ce...
Molecular determinants of condensate composition
Biomolecular condensates are non-stochiometric assemblies that organize cellular matter
in space and time. Despite much work, many questions remain regarding what determines
the recruitment and exclus...
www.cell.com
January 17, 2025 at 3:07 AM
Molecular determinants of condensate composition: Molecular Cell www.cell.com/molecular-ce...