Simone Andrea Biagini 🏳️🌈
@sabiagini.bsky.social
Human Population Geneticist 💀🧬 #aDNA | Bioinformatician 👨💻 | Diversity&Inclusion in Academia 🌈 | Member of the SMBE IDEA Task Force @smbe-idea.bsky.social ✨ | Theater 🎭 | he/him | 🗣️🇮🇹🇬🇧🇪🇸🏳️🌈
I'm truly confused 🤔
I asked #ChatGPT to summarize a series of notes I had on a statistical interpretation. It then asked me if I wanted a visual summary of the topic (again, statistics, numbers, etc.). I said yes, just yes. This is what it created:
#AcademicSky #Bioinformatics
I asked #ChatGPT to summarize a series of notes I had on a statistical interpretation. It then asked me if I wanted a visual summary of the topic (again, statistics, numbers, etc.). I said yes, just yes. This is what it created:
#AcademicSky #Bioinformatics
October 16, 2025 at 2:59 PM
I'm truly confused 🤔
I asked #ChatGPT to summarize a series of notes I had on a statistical interpretation. It then asked me if I wanted a visual summary of the topic (again, statistics, numbers, etc.). I said yes, just yes. This is what it created:
#AcademicSky #Bioinformatics
I asked #ChatGPT to summarize a series of notes I had on a statistical interpretation. It then asked me if I wanted a visual summary of the topic (again, statistics, numbers, etc.). I said yes, just yes. This is what it created:
#AcademicSky #Bioinformatics
🔥 Don't miss the opportunity! Submit your proposal 𝙉𝙊𝙒! 🌈
#AcademicSky #IDEA #SMBE2026
@official-smbe.bsky.social
#AcademicSky #IDEA #SMBE2026
@official-smbe.bsky.social
September 30, 2025 at 2:55 PM
🔥 Don't miss the opportunity! Submit your proposal 𝙉𝙊𝙒! 🌈
#AcademicSky #IDEA #SMBE2026
@official-smbe.bsky.social
#AcademicSky #IDEA #SMBE2026
@official-smbe.bsky.social
Anything to promote my new paper (and yes that includes this photo). I put six years of my mental health into this one 😅🧬🔥
📝 Go read it! ⬇️
🔗 genome.cshlp.org/content/35/9...
#AcademicSky
📝 Go read it! ⬇️
🔗 genome.cshlp.org/content/35/9...
#AcademicSky
September 4, 2025 at 6:50 PM
Anything to promote my new paper (and yes that includes this photo). I put six years of my mental health into this one 😅🧬🔥
📝 Go read it! ⬇️
🔗 genome.cshlp.org/content/35/9...
#AcademicSky
📝 Go read it! ⬇️
🔗 genome.cshlp.org/content/35/9...
#AcademicSky
When applied to 𝗽𝗼𝗹𝘆𝗴𝗲𝗻𝗶𝗰 𝘀𝗰𝗼𝗿𝗲𝘀 (PGS) for height, GDI was less effective. GDI-filtered data explained 14% of the variance, while the best-performing approach (PGSHapMap) explained 23.7% using a smaller set of common variants.
September 3, 2025 at 10:35 PM
When applied to 𝗽𝗼𝗹𝘆𝗴𝗲𝗻𝗶𝗰 𝘀𝗰𝗼𝗿𝗲𝘀 (PGS) for height, GDI was less effective. GDI-filtered data explained 14% of the variance, while the best-performing approach (PGSHapMap) explained 23.7% using a smaller set of common variants.
✅ 𝗔𝗳𝘁𝗲𝗿 𝗮𝗽𝗽𝗹𝘆𝗶𝗻𝗴 𝗚𝗗𝗜, 𝘁𝗵𝗲 𝗯𝗮𝘁𝗰𝗵 𝗲𝗳𝗳𝗲𝗰𝘁 𝗱𝗶𝘀𝗮𝗽𝗽𝗲𝗮𝗿𝘀! ✨
PCA/UMAP of >27,000 Belgian samples.
🇪🇺 89.17% European ancestry
🌍🌏 10.83% African/Asian ancestries
🇧🇪 A snapshot of Belgium’s current diversity!
PCA/UMAP of >27,000 Belgian samples.
🇪🇺 89.17% European ancestry
🌍🌏 10.83% African/Asian ancestries
🇧🇪 A snapshot of Belgium’s current diversity!
September 3, 2025 at 10:35 PM
✅ 𝗔𝗳𝘁𝗲𝗿 𝗮𝗽𝗽𝗹𝘆𝗶𝗻𝗴 𝗚𝗗𝗜, 𝘁𝗵𝗲 𝗯𝗮𝘁𝗰𝗵 𝗲𝗳𝗳𝗲𝗰𝘁 𝗱𝗶𝘀𝗮𝗽𝗽𝗲𝗮𝗿𝘀! ✨
PCA/UMAP of >27,000 Belgian samples.
🇪🇺 89.17% European ancestry
🌍🌏 10.83% African/Asian ancestries
🇧🇪 A snapshot of Belgium’s current diversity!
PCA/UMAP of >27,000 Belgian samples.
🇪🇺 89.17% European ancestry
🌍🌏 10.83% African/Asian ancestries
🇧🇪 A snapshot of Belgium’s current diversity!
❌ Without GDI, both PCA and UMAP show a strong batch effect. NIPS samples cluster apart due to low imputation quality.
September 3, 2025 at 10:35 PM
❌ Without GDI, both PCA and UMAP show a strong batch effect. NIPS samples cluster apart due to low imputation quality.
We introduce 🅶🅳🅸 (GenotypeProbability-Dosage-INFOscore), a 𝗯𝗮𝘁𝗰𝗵-𝗹𝗲𝘃𝗲𝗹 𝗳𝗶𝗹𝘁𝗲𝗿𝗶𝗻𝗴 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵.
GDI combines three QC metrics to maximize accuracy while minimizing variant loss ✨
GDI combines three QC metrics to maximize accuracy while minimizing variant loss ✨
September 3, 2025 at 10:35 PM
We introduce 🅶🅳🅸 (GenotypeProbability-Dosage-INFOscore), a 𝗯𝗮𝘁𝗰𝗵-𝗹𝗲𝘃𝗲𝗹 𝗳𝗶𝗹𝘁𝗲𝗿𝗶𝗻𝗴 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵.
GDI combines three QC metrics to maximize accuracy while minimizing variant loss ✨
GDI combines three QC metrics to maximize accuracy while minimizing variant loss ✨
In a test on a batch of 3 genomes, the standard filter (GP≥0.99) keeps only 49.2% of sites. 𝗪𝗶𝘁𝗵 𝗹𝗮𝗿𝗴𝗲𝗿 𝗰𝗼𝗵𝗼𝗿𝘁𝘀, 𝘁𝗵𝗲 𝗹𝗼𝘀𝘀 𝗯𝗲𝗰𝗼𝗺𝗲𝘀 𝗱𝗿𝗮𝗺𝗮𝘁𝗶𝗰 😭
September 3, 2025 at 10:35 PM
In a test on a batch of 3 genomes, the standard filter (GP≥0.99) keeps only 49.2% of sites. 𝗪𝗶𝘁𝗵 𝗹𝗮𝗿𝗴𝗲𝗿 𝗰𝗼𝗵𝗼𝗿𝘁𝘀, 𝘁𝗵𝗲 𝗹𝗼𝘀𝘀 𝗯𝗲𝗰𝗼𝗺𝗲𝘀 𝗱𝗿𝗮𝗺𝗮𝘁𝗶𝗰 😭
On average, our NIPS data has very low coverage (~0.15x). Standard quality filters applied per sample cause 𝗰𝘂𝗺𝘂𝗹𝗮𝘁𝗶𝘃𝗲 𝗺𝗶𝘀𝘀𝗶𝗻𝗴𝗻𝗲𝘀𝘀: when combining thousands of genomes, most variants get lost.
September 3, 2025 at 10:35 PM
On average, our NIPS data has very low coverage (~0.15x). Standard quality filters applied per sample cause 𝗰𝘂𝗺𝘂𝗹𝗮𝘁𝗶𝘃𝗲 𝗺𝗶𝘀𝘀𝗶𝗻𝗴𝗻𝗲𝘀𝘀: when combining thousands of genomes, most variants get lost.
Let's talk about legends coming true at poster 8! 🧬☠️ #ISBA11 @isba11.bsky.social
August 29, 2025 at 10:55 AM
Let's talk about legends coming true at poster 8! 🧬☠️ #ISBA11 @isba11.bsky.social
No expat here. I am an #immigrant. I left because my country failed me. Italy talks about brain drain as if it's a tragic accident. It is not. It is the direct result of years of neglect and political incompetence. I did not leave by choice. I was pushed away. No expat here. I am a proud immigrant.
July 22, 2025 at 6:42 AM
No expat here. I am an #immigrant. I left because my country failed me. Italy talks about brain drain as if it's a tragic accident. It is not. It is the direct result of years of neglect and political incompetence. I did not leave by choice. I was pushed away. No expat here. I am a proud immigrant.
May 21, 2025 at 12:28 PM
April 25 is Italy’s Liberation Day: the end of Nazi-Fascist rule in 1945. We honor the partisans and all who fought for freedom. It’s not just history, it’s a living commitment. Long live anti-fascist Italy, always.
Viva l'Italia antifascista, sempre.
#25Aprile #antifascismo
Viva l'Italia antifascista, sempre.
#25Aprile #antifascismo
April 25, 2025 at 10:04 AM
April 25 is Italy’s Liberation Day: the end of Nazi-Fascist rule in 1945. We honor the partisans and all who fought for freedom. It’s not just history, it’s a living commitment. Long live anti-fascist Italy, always.
Viva l'Italia antifascista, sempre.
#25Aprile #antifascismo
Viva l'Italia antifascista, sempre.
#25Aprile #antifascismo
In that limbo of "Reply All" where you reply to yourself and 8 other people who, without you knowing, are out of office. So for every email you send, you get 9 back. All completely useless. #AcademicSky
March 20, 2025 at 2:08 PM
In that limbo of "Reply All" where you reply to yourself and 8 other people who, without you knowing, are out of office. So for every email you send, you get 9 back. All completely useless. #AcademicSky
I told myself I’d finish my presentation today. Adorable how I forgot how ridiculously picky I am. #AcademicSky
March 12, 2025 at 6:18 PM
I told myself I’d finish my presentation today. Adorable how I forgot how ridiculously picky I am. #AcademicSky
Another orbit around the sun completed 🎂🎈🎉
February 28, 2025 at 10:46 PM
Another orbit around the sun completed 🎂🎈🎉
February 3, 2025 at 9:52 AM
Show me you in a hat 🧢
December 13, 2024 at 8:32 PM
Show me you in a hat 🧢
You study, grow intellectually, become an academic, and then decide that switching out your wardrobe is a brilliant idea. Spoiler: it’s not. #AcademicSky
December 8, 2024 at 4:37 PM
You study, grow intellectually, become an academic, and then decide that switching out your wardrobe is a brilliant idea. Spoiler: it’s not. #AcademicSky
I stumbled on this insane story: Every year, Sweden builds a giant straw #Christmas goat in Gävle. And every year, people try to burn it down 🔥
Despite guards and cameras, 42 out of 58 goats have been destroyed since 1966. I’m obsessed with this #ChristmasGoat 🐐🎄! Know a wilder story? #AcademicSky
Despite guards and cameras, 42 out of 58 goats have been destroyed since 1966. I’m obsessed with this #ChristmasGoat 🐐🎄! Know a wilder story? #AcademicSky
December 2, 2024 at 4:35 PM
I stumbled on this insane story: Every year, Sweden builds a giant straw #Christmas goat in Gävle. And every year, people try to burn it down 🔥
Despite guards and cameras, 42 out of 58 goats have been destroyed since 1966. I’m obsessed with this #ChristmasGoat 🐐🎄! Know a wilder story? #AcademicSky
Despite guards and cameras, 42 out of 58 goats have been destroyed since 1966. I’m obsessed with this #ChristmasGoat 🐐🎄! Know a wilder story? #AcademicSky
Considering how often I tell #ChatGPT to f*** off, I didn’t expect it to be so nice! #haiku #AcademicSky
November 30, 2024 at 10:13 AM
Considering how often I tell #ChatGPT to f*** off, I didn’t expect it to be so nice! #haiku #AcademicSky
Show me the women who raised you.
Life is better when you don’t take things too seriously.
Life is better when you don’t take things too seriously.
November 29, 2024 at 9:20 PM
Show me the women who raised you.
Life is better when you don’t take things too seriously.
Life is better when you don’t take things too seriously.
4 pics from your phone that have your energy that aren't selfies.
November 27, 2024 at 9:47 AM
4 pics from your phone that have your energy that aren't selfies.