Rudy Gatta
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rudyshecat.bsky.social
Rudy Gatta
@rudyshecat.bsky.social
60 followers 44 following 13 posts
From Ravenna🇮🇹Now in Boston🇺🇸 kidnapped by my crazy wife @menicgiulia👩‍🔬Journalist✍🏼 Knight🎖️Marathoner🏃‍♂️ Family’s recipes @lacucinadelloracolo 🍽️
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Reposted by Rudy Gatta
menicgiulia.bsky.social
3/ 🧑‍🔬🏛️ @barabasi.bsky.social Joseph Loscalzo
@harvardmed.bsky.social @massgeneralbrigham.bsky.social @nunetsi.bsky.social
#NutritionScience #AI #NetworkMedicine
December 30, 2024 at 4:33 PM
Reposted by Rudy Gatta
menicgiulia.bsky.social
2/ Fast forward to today: My co-authors and I distilled this journey into "Decoding the Foodome: Molecular Networks Connecting Diet and Health" for @annualreviews.bsky.social
Perfect reading for New Year’s resolutions about rethinking diets & research 😉
👉 Read it here: shorturl.at/GQeaW
The dark matter of nutrition. The United States Department of Agriculture (USDA) has systematically measured 188 nutritional components that encompass essential micro- and macronutrients related primarily to energy intake and vitamin deficiencies. Although this knowledge has been transformative for the health sciences, these nutritional components represent only a fraction of the more than 139,000 chemicals we have collected, many of which have documented effects. For example, the 69 nutrients documented by the USDA Standard Reference Legacy database for raw garlic include vitamins such as ascorbic acid and amino acids such as alanine but miss important bioactive compounds such as allicin, ajoene, and p-coumaric acid. The number of health effects/bioactivities documented in FooDB is shown for each compound. The network neighborhood of sulforaphane’s targets in the protein–protein interaction network generates a connected component comprising 49 targets, surrounded by 9 additional isolated targets. Green indicates both sulforaphane’s targets and the binding links connecting them. Gray indicates proteins close to sulforaphane’s targets. Within the same region of the interactome are proteins that are epigenetic modifiers (blue). Proteins that are both sulforaphane’s targets and associated with a therapeutic area are filled with the color of the selected therapeutic area, while their border is colored green.
December 30, 2024 at 4:33 PM