These findings suggest there may be distinct mechanisms underlying different depression trajectories, and highlight opportunities for preventing/reducing adverse cardiometabolic health in subgroups of young people with depression. 5/5

In particular, the adulthood-onset group showed widespread classical immunometabolic changes, including ones known to predict cardiometabolic disease, whereas the adolescent-persistent group had higher BMI both in childhood and adulthood with few immunometabolic changes. 4/5

These depression trajectories show different patterns of associations with various blood immune proteomic, metabolomic and clinical biochemistry markers. 3/5

Using rich longitudinal data from ALSPAC, we identified four distinct depression trajectories between childhood and early adulthood (low-stable, adolescent-limited, adolescent-persistent and adulthood-onset). 2/5