RPTH
@rpth.bsky.social
Research and Practice in Thrombosis and Haemostasis (#RPTH). #OpenAccess journal of the ISTH.
Intestinal transplantation can have complex hemostatic complications.
This study of 145 transplants reports bleeding (38%) and thrombosis (26%) in their patient cohort.
Read more here to learn about the risks and management! www.rpthjournal.org/article/S247...
This study of 145 transplants reports bleeding (38%) and thrombosis (26%) in their patient cohort.
Read more here to learn about the risks and management! www.rpthjournal.org/article/S247...
September 13, 2025 at 6:02 PM
Intestinal transplantation can have complex hemostatic complications.
This study of 145 transplants reports bleeding (38%) and thrombosis (26%) in their patient cohort.
Read more here to learn about the risks and management! www.rpthjournal.org/article/S247...
This study of 145 transplants reports bleeding (38%) and thrombosis (26%) in their patient cohort.
Read more here to learn about the risks and management! www.rpthjournal.org/article/S247...
Combined oral contraception (COC) alters hemostasis in ways standard labs may underestimate.
Thrombin generation assays with anti-PS and anti-TFPI antibodies revealed a marked reduction in anticoagulant activity after just 3 months of COC use.
www.rpthjournal.org/article/S247...
Thrombin generation assays with anti-PS and anti-TFPI antibodies revealed a marked reduction in anticoagulant activity after just 3 months of COC use.
www.rpthjournal.org/article/S247...
September 11, 2025 at 6:02 PM
Combined oral contraception (COC) alters hemostasis in ways standard labs may underestimate.
Thrombin generation assays with anti-PS and anti-TFPI antibodies revealed a marked reduction in anticoagulant activity after just 3 months of COC use.
www.rpthjournal.org/article/S247...
Thrombin generation assays with anti-PS and anti-TFPI antibodies revealed a marked reduction in anticoagulant activity after just 3 months of COC use.
www.rpthjournal.org/article/S247...
Gynecological and obstetric complications in women with congenital fibrinogen deficiencies:
In qualitative fibrinogen deficiencies, the rates of live birth, postpartum hemorrhage, and miscarriage were 58%, 47%, and 42%, respectively.
See the details here:
www.rpthjournal.org/article/S247...
In qualitative fibrinogen deficiencies, the rates of live birth, postpartum hemorrhage, and miscarriage were 58%, 47%, and 42%, respectively.
See the details here:
www.rpthjournal.org/article/S247...
July 31, 2025 at 12:01 PM
Gynecological and obstetric complications in women with congenital fibrinogen deficiencies:
In qualitative fibrinogen deficiencies, the rates of live birth, postpartum hemorrhage, and miscarriage were 58%, 47%, and 42%, respectively.
See the details here:
www.rpthjournal.org/article/S247...
In qualitative fibrinogen deficiencies, the rates of live birth, postpartum hemorrhage, and miscarriage were 58%, 47%, and 42%, respectively.
See the details here:
www.rpthjournal.org/article/S247...
This excellent commentary from Tzu-Fei Wang discusses a recent study about bleeding risk after a fall in people taking anticoagulants for atrial fibrillation.🩸
Commentary: www.rpthjournal.org/article/S247...
Article: www.rpthjournal.org/article/S247...
Commentary: www.rpthjournal.org/article/S247...
Article: www.rpthjournal.org/article/S247...
July 30, 2025 at 12:01 PM
This excellent commentary from Tzu-Fei Wang discusses a recent study about bleeding risk after a fall in people taking anticoagulants for atrial fibrillation.🩸
Commentary: www.rpthjournal.org/article/S247...
Article: www.rpthjournal.org/article/S247...
Commentary: www.rpthjournal.org/article/S247...
Article: www.rpthjournal.org/article/S247...
New insight into thrombotic mechanisms of SARS-CoV2 infection?
Using drosophila genetic screening, Quan Zhang and team identified orf7a as a trigger for endothelial activation and release of von Willebrand factor, and may result in thrombosis.
www.rpthjournal.org/article/S247...
Using drosophila genetic screening, Quan Zhang and team identified orf7a as a trigger for endothelial activation and release of von Willebrand factor, and may result in thrombosis.
www.rpthjournal.org/article/S247...
July 29, 2025 at 12:02 PM
New insight into thrombotic mechanisms of SARS-CoV2 infection?
Using drosophila genetic screening, Quan Zhang and team identified orf7a as a trigger for endothelial activation and release of von Willebrand factor, and may result in thrombosis.
www.rpthjournal.org/article/S247...
Using drosophila genetic screening, Quan Zhang and team identified orf7a as a trigger for endothelial activation and release of von Willebrand factor, and may result in thrombosis.
www.rpthjournal.org/article/S247...
Acetaldehyde is a pollutant found in tobacco and eCig smoke, cosmetic products, and the product of alcohol metabolism. And did you know it can affect fibrin structure?
Read more about the effect of this common toxicant on the fibrinolytic system!
www.rpthjournal.org/article/S247...
Read more about the effect of this common toxicant on the fibrinolytic system!
www.rpthjournal.org/article/S247...
July 28, 2025 at 12:01 PM
Acetaldehyde is a pollutant found in tobacco and eCig smoke, cosmetic products, and the product of alcohol metabolism. And did you know it can affect fibrin structure?
Read more about the effect of this common toxicant on the fibrinolytic system!
www.rpthjournal.org/article/S247...
Read more about the effect of this common toxicant on the fibrinolytic system!
www.rpthjournal.org/article/S247...
New study from Steven Humphreys reveals that arterial and venous endothelial cells elongate and remodel differentially in response to flow rate.
Arterial endothelial cells are more responsive to inflammation and significantly delay clot breakdown.
More here: www.rpthjournal.org/article/S247...
Arterial endothelial cells are more responsive to inflammation and significantly delay clot breakdown.
More here: www.rpthjournal.org/article/S247...
July 27, 2025 at 2:01 PM
New study from Steven Humphreys reveals that arterial and venous endothelial cells elongate and remodel differentially in response to flow rate.
Arterial endothelial cells are more responsive to inflammation and significantly delay clot breakdown.
More here: www.rpthjournal.org/article/S247...
Arterial endothelial cells are more responsive to inflammation and significantly delay clot breakdown.
More here: www.rpthjournal.org/article/S247...
A small panel of VWF variants were investigated for expression and function - and how they might cause Von Willebrand Disease.
Golzar Mobayen and team reveal that the D4 and C-domains of VWF might play a role!
📖 www.sciencedirect.com/science/arti...
Golzar Mobayen and team reveal that the D4 and C-domains of VWF might play a role!
📖 www.sciencedirect.com/science/arti...
July 26, 2025 at 2:01 PM
A small panel of VWF variants were investigated for expression and function - and how they might cause Von Willebrand Disease.
Golzar Mobayen and team reveal that the D4 and C-domains of VWF might play a role!
📖 www.sciencedirect.com/science/arti...
Golzar Mobayen and team reveal that the D4 and C-domains of VWF might play a role!
📖 www.sciencedirect.com/science/arti...
Hanqiang Deng provides excellent commentary on an outstanding article about heterogeneous responses to shear stress in different endothelial cell subtypes.
Commentary here: www.rpthjournal.org/article/S247...
Original Article by Allaura Cox and Christopher Ng: www.rpthjournal.org/article/S247...
Commentary here: www.rpthjournal.org/article/S247...
Original Article by Allaura Cox and Christopher Ng: www.rpthjournal.org/article/S247...
July 25, 2025 at 12:01 PM
Hanqiang Deng provides excellent commentary on an outstanding article about heterogeneous responses to shear stress in different endothelial cell subtypes.
Commentary here: www.rpthjournal.org/article/S247...
Original Article by Allaura Cox and Christopher Ng: www.rpthjournal.org/article/S247...
Commentary here: www.rpthjournal.org/article/S247...
Original Article by Allaura Cox and Christopher Ng: www.rpthjournal.org/article/S247...
This study from Eva Kempers and team examined menstrual blood loss and related quality of life among women on antiplatelet therapy and a control group.
Their data reveal that both outcomes were comparable, great news for women who need antiplatelet therapy.
www.rpthjournal.org/article/S247...
Their data reveal that both outcomes were comparable, great news for women who need antiplatelet therapy.
www.rpthjournal.org/article/S247...
July 24, 2025 at 12:00 PM
This study from Eva Kempers and team examined menstrual blood loss and related quality of life among women on antiplatelet therapy and a control group.
Their data reveal that both outcomes were comparable, great news for women who need antiplatelet therapy.
www.rpthjournal.org/article/S247...
Their data reveal that both outcomes were comparable, great news for women who need antiplatelet therapy.
www.rpthjournal.org/article/S247...
This new study investigates adenoviral vector vaccine-associated thrombosis/thrombocytopenia risk.
✅ Adenoviral vectors can infect megakaryocytes
✅ Concurrent infection may increase chemokine receptor expression
Check out the results here:
www.rpthjournal.org/article/S247...
✅ Adenoviral vectors can infect megakaryocytes
✅ Concurrent infection may increase chemokine receptor expression
Check out the results here:
www.rpthjournal.org/article/S247...
July 23, 2025 at 6:00 PM
This new study investigates adenoviral vector vaccine-associated thrombosis/thrombocytopenia risk.
✅ Adenoviral vectors can infect megakaryocytes
✅ Concurrent infection may increase chemokine receptor expression
Check out the results here:
www.rpthjournal.org/article/S247...
✅ Adenoviral vectors can infect megakaryocytes
✅ Concurrent infection may increase chemokine receptor expression
Check out the results here:
www.rpthjournal.org/article/S247...
Current ICD codes make it difficult to track venous thrombosis incidence in real time. This original article suggests use of "I26" which has high specificity for VTE in the Unite States, and may help capture the incidence of PE.
💻 read more about it here
www.rpthjournal.org/article/S247...
💻 read more about it here
www.rpthjournal.org/article/S247...
July 18, 2025 at 12:03 PM
Current ICD codes make it difficult to track venous thrombosis incidence in real time. This original article suggests use of "I26" which has high specificity for VTE in the Unite States, and may help capture the incidence of PE.
💻 read more about it here
www.rpthjournal.org/article/S247...
💻 read more about it here
www.rpthjournal.org/article/S247...
How do different anti-FXa activity assays stack up when measuring plasma levels of DOAC?
The PAUSE study reveals that although there is variability, it is not clinically relevant.
📊 Read more about the study and results here: www.rpthjournal.org/article/S247...
The PAUSE study reveals that although there is variability, it is not clinically relevant.
📊 Read more about the study and results here: www.rpthjournal.org/article/S247...
July 17, 2025 at 12:04 PM
How do different anti-FXa activity assays stack up when measuring plasma levels of DOAC?
The PAUSE study reveals that although there is variability, it is not clinically relevant.
📊 Read more about the study and results here: www.rpthjournal.org/article/S247...
The PAUSE study reveals that although there is variability, it is not clinically relevant.
📊 Read more about the study and results here: www.rpthjournal.org/article/S247...
Great news for patient care!
This study investigated if anticoagulation in A Fib patients increases bleeding risk in recurrent fallers. Fortunately , no association with major bleeding was found!
www.rpthjournal.org/article/S247...
This study investigated if anticoagulation in A Fib patients increases bleeding risk in recurrent fallers. Fortunately , no association with major bleeding was found!
www.rpthjournal.org/article/S247...
July 15, 2025 at 12:03 PM
Great news for patient care!
This study investigated if anticoagulation in A Fib patients increases bleeding risk in recurrent fallers. Fortunately , no association with major bleeding was found!
www.rpthjournal.org/article/S247...
This study investigated if anticoagulation in A Fib patients increases bleeding risk in recurrent fallers. Fortunately , no association with major bleeding was found!
www.rpthjournal.org/article/S247...
This study from Thor-David Halstensen and team externally validated the new DAYS score for predicting DVT . 📊
Read more to find out how it stacks up compared to other risk prediction scores
www.rpthjournal.org/article/S247...
Read more to find out how it stacks up compared to other risk prediction scores
www.rpthjournal.org/article/S247...
July 14, 2025 at 12:02 PM
This study from Thor-David Halstensen and team externally validated the new DAYS score for predicting DVT . 📊
Read more to find out how it stacks up compared to other risk prediction scores
www.rpthjournal.org/article/S247...
Read more to find out how it stacks up compared to other risk prediction scores
www.rpthjournal.org/article/S247...
❤️🔥 Thrombosis risk after an acute myocardial infarction
This retrospective study reveals that lack of revascularization may be associated with higher mortality in those who have a LV thrombus.
📖 www.rpthjournal.org/article/S247...
This retrospective study reveals that lack of revascularization may be associated with higher mortality in those who have a LV thrombus.
📖 www.rpthjournal.org/article/S247...
July 13, 2025 at 2:01 PM
❤️🔥 Thrombosis risk after an acute myocardial infarction
This retrospective study reveals that lack of revascularization may be associated with higher mortality in those who have a LV thrombus.
📖 www.rpthjournal.org/article/S247...
This retrospective study reveals that lack of revascularization may be associated with higher mortality in those who have a LV thrombus.
📖 www.rpthjournal.org/article/S247...
How about a double feature for a weekend read? ☕
This commentary "Tougher clots, safer lives?" by Zsuzsa Bagoly discusses a recent paper from
@valtutwiler.bsky.social.
Commentary: www.rpthjournal.org/article/S247...
Original Paper: www.rpthjournal.org/article/S247...
This commentary "Tougher clots, safer lives?" by Zsuzsa Bagoly discusses a recent paper from
@valtutwiler.bsky.social.
Commentary: www.rpthjournal.org/article/S247...
Original Paper: www.rpthjournal.org/article/S247...
July 12, 2025 at 2:02 PM
How about a double feature for a weekend read? ☕
This commentary "Tougher clots, safer lives?" by Zsuzsa Bagoly discusses a recent paper from
@valtutwiler.bsky.social.
Commentary: www.rpthjournal.org/article/S247...
Original Paper: www.rpthjournal.org/article/S247...
This commentary "Tougher clots, safer lives?" by Zsuzsa Bagoly discusses a recent paper from
@valtutwiler.bsky.social.
Commentary: www.rpthjournal.org/article/S247...
Original Paper: www.rpthjournal.org/article/S247...
Maternal antiphospholipid antibodies can cross the placental barrier to neonates - but does this increase risk of neonatal thrombosis? 🤰
This case report describes the first known neonatal intracardiac thrombosis -
www.rpthjournal.org/article/S247...
This case report describes the first known neonatal intracardiac thrombosis -
www.rpthjournal.org/article/S247...
July 10, 2025 at 12:02 PM
Maternal antiphospholipid antibodies can cross the placental barrier to neonates - but does this increase risk of neonatal thrombosis? 🤰
This case report describes the first known neonatal intracardiac thrombosis -
www.rpthjournal.org/article/S247...
This case report describes the first known neonatal intracardiac thrombosis -
www.rpthjournal.org/article/S247...
This team studied the effects of prothrombotic single nucleotide polymorphisms on VTE risk during atrial fibrillation.
✅ Factor V Leiden was associated with risk of VTE during A Fib.
⛔ The 5-SNP genetic risk score was not associated with VTE risk during A Fib.
www.rpthjournal.org/article/S247...
✅ Factor V Leiden was associated with risk of VTE during A Fib.
⛔ The 5-SNP genetic risk score was not associated with VTE risk during A Fib.
www.rpthjournal.org/article/S247...
July 9, 2025 at 12:02 PM
This team studied the effects of prothrombotic single nucleotide polymorphisms on VTE risk during atrial fibrillation.
✅ Factor V Leiden was associated with risk of VTE during A Fib.
⛔ The 5-SNP genetic risk score was not associated with VTE risk during A Fib.
www.rpthjournal.org/article/S247...
✅ Factor V Leiden was associated with risk of VTE during A Fib.
⛔ The 5-SNP genetic risk score was not associated with VTE risk during A Fib.
www.rpthjournal.org/article/S247...
Fabulous commentary from Julie Jaffray, discussing if BMI influences recovery from pediatric venous thrombosis. www.rpthjournal.org/article/S247...
Original Article Here: www.rpthjournal.org/article/S247...
Original Article Here: www.rpthjournal.org/article/S247...
June 19, 2025 at 12:02 PM
Fabulous commentary from Julie Jaffray, discussing if BMI influences recovery from pediatric venous thrombosis. www.rpthjournal.org/article/S247...
Original Article Here: www.rpthjournal.org/article/S247...
Original Article Here: www.rpthjournal.org/article/S247...
What happens to platelets during recovery from trauma?
New study from Andrea Rossetto and team demonstrates that prolonged thrombocytopenia is associated with higher rates of organ dysfunction and need for support.
www.rpthjournal.org/article/S247...
New study from Andrea Rossetto and team demonstrates that prolonged thrombocytopenia is associated with higher rates of organ dysfunction and need for support.
www.rpthjournal.org/article/S247...
June 18, 2025 at 1:04 PM
What happens to platelets during recovery from trauma?
New study from Andrea Rossetto and team demonstrates that prolonged thrombocytopenia is associated with higher rates of organ dysfunction and need for support.
www.rpthjournal.org/article/S247...
New study from Andrea Rossetto and team demonstrates that prolonged thrombocytopenia is associated with higher rates of organ dysfunction and need for support.
www.rpthjournal.org/article/S247...
🧪 A novel quantitative assay to evaluate fibrinolysis!
Robert Medcalf and team share the Halo Fluorescence Fibrinolysis (HoFF) test in this new Methodological Article.
www.rpthjournal.org/article/S247...
😇
Robert Medcalf and team share the Halo Fluorescence Fibrinolysis (HoFF) test in this new Methodological Article.
www.rpthjournal.org/article/S247...
😇
June 13, 2025 at 1:04 PM
🧪 A novel quantitative assay to evaluate fibrinolysis!
Robert Medcalf and team share the Halo Fluorescence Fibrinolysis (HoFF) test in this new Methodological Article.
www.rpthjournal.org/article/S247...
😇
Robert Medcalf and team share the Halo Fluorescence Fibrinolysis (HoFF) test in this new Methodological Article.
www.rpthjournal.org/article/S247...
😇
🚑 Trauma-induced coagulopathy leads to depletion of clotting factors, like FV.
This study from Pieter H Sloos and team looks at the impact of reduced FV activity on outcomes in trauma patients.
www.rpthjournal.org/article/S247...
This study from Pieter H Sloos and team looks at the impact of reduced FV activity on outcomes in trauma patients.
www.rpthjournal.org/article/S247...
June 3, 2025 at 1:07 PM
🚑 Trauma-induced coagulopathy leads to depletion of clotting factors, like FV.
This study from Pieter H Sloos and team looks at the impact of reduced FV activity on outcomes in trauma patients.
www.rpthjournal.org/article/S247...
This study from Pieter H Sloos and team looks at the impact of reduced FV activity on outcomes in trauma patients.
www.rpthjournal.org/article/S247...
Exploring clot structure and stability 🩸
Biomechanical studies from @valtutwiler.bsky.social shows that FXIIIa crosslinking increases clot toughness and strength 💪
www.rpthjournal.org/article/S247...
Biomechanical studies from @valtutwiler.bsky.social shows that FXIIIa crosslinking increases clot toughness and strength 💪
www.rpthjournal.org/article/S247...
June 2, 2025 at 1:05 PM
Exploring clot structure and stability 🩸
Biomechanical studies from @valtutwiler.bsky.social shows that FXIIIa crosslinking increases clot toughness and strength 💪
www.rpthjournal.org/article/S247...
Biomechanical studies from @valtutwiler.bsky.social shows that FXIIIa crosslinking increases clot toughness and strength 💪
www.rpthjournal.org/article/S247...
New study protocol from PRONOSPECT!
Study recommends use of SPECT/CT to visualize residual pulmonary vascular obstruction after pulmonary embolism as a prediction tool for recurrence.
www.rpthjournal.org/article/S247...
#pulmonaryembolism
Study recommends use of SPECT/CT to visualize residual pulmonary vascular obstruction after pulmonary embolism as a prediction tool for recurrence.
www.rpthjournal.org/article/S247...
#pulmonaryembolism
May 23, 2025 at 1:03 PM
New study protocol from PRONOSPECT!
Study recommends use of SPECT/CT to visualize residual pulmonary vascular obstruction after pulmonary embolism as a prediction tool for recurrence.
www.rpthjournal.org/article/S247...
#pulmonaryembolism
Study recommends use of SPECT/CT to visualize residual pulmonary vascular obstruction after pulmonary embolism as a prediction tool for recurrence.
www.rpthjournal.org/article/S247...
#pulmonaryembolism