Scott Rothbart
@rothbartlab.bsky.social
Professor @ Van Andel Institute | DNA methylation | histone PTMs |
cancer epigenetics | functional proteomics | rothbartlab.vai.org
cancer epigenetics | functional proteomics | rothbartlab.vai.org
Reposted by Scott Rothbart
I am excited to announce that after a decade of service to the U of Florida during which the @ufhealthcancer.bsky.social received NCI designation, in January 2026 I will be assuming the role of President and Chief Scientific Officer of the @vai.org.
www.vai.org/article/emin...
www.vai.org/article/emin...
Eminent physician-scientist Dr. Jonathan D. Licht to serve as next president and chief scientific officer of Van Andel Institute – Van Andel Institute
Dr. Jonathan D. Licht has been selected as the next president and chief scientific officer of Van Andel Institute, effective January 2026.
www.vai.org
October 29, 2025 at 6:20 PM
I am excited to announce that after a decade of service to the U of Florida during which the @ufhealthcancer.bsky.social received NCI designation, in January 2026 I will be assuming the role of President and Chief Scientific Officer of the @vai.org.
www.vai.org/article/emin...
www.vai.org/article/emin...
Reposted by Scott Rothbart
A study led by VAI’s @rothbartlab.bsky.social and his team sheds light on how interwoven epigenetic layers work together to sustain cancer cell survival. Their findings reveal a potential weak spot that could be leveraged to improve treatment.
Pinpointing weaknesses in cancer’s armor – Van Andel Institute
Read about Pinpointing weaknesses in cancer’s armor on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.
www.vai.org
April 21, 2025 at 8:18 PM
A study led by VAI’s @rothbartlab.bsky.social and his team sheds light on how interwoven epigenetic layers work together to sustain cancer cell survival. Their findings reveal a potential weak spot that could be leveraged to improve treatment.
Reposted by Scott Rothbart
Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications!
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
2025 Histone and DNA Modifications (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Histone and DNA Modifications (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
February 14, 2025 at 3:48 PM
Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications!
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
Happy holidays from our lab family to you and yours!
December 15, 2024 at 5:08 AM
Happy holidays from our lab family to you and yours!
Short’s was Michigan’s best microbrewery even before this genius holiday marketing campaign! #bringmebacksomethingfrench
December 10, 2024 at 1:11 AM
Short’s was Michigan’s best microbrewery even before this genius holiday marketing campaign! #bringmebacksomethingfrench
Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics
DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
Liu et al. report that DNMT1 inhibition causes transient accumulation of hemi-methylated
DNA at CpG islands, which stimulates UHRF1-mediated H3K18ub. This enhances SUV39H1/H2
activity, nucleates new H...
www.cell.com
December 4, 2024 at 3:02 AM
Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics
Reposted by Scott Rothbart
So excited to share our new paper working w/ David Lyden, Han Kim & Jackie Bromberg (WCM), led by the amazing Inbal Wortzel & Ifé Akano where we revealed a new & unexpected function for chromatin on the surface of exosomes in #cancer #metastasis @ Nature Cancer!
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression - Nature Cancer
Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 (APAF1), support DNA packaging on the surface of tumor-derived extracellular vesicles that ar...
www.nature.com
December 4, 2024 at 2:09 AM
So excited to share our new paper working w/ David Lyden, Han Kim & Jackie Bromberg (WCM), led by the amazing Inbal Wortzel & Ifé Akano where we revealed a new & unexpected function for chromatin on the surface of exosomes in #cancer #metastasis @ Nature Cancer!
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Excited to share the first of 2 new papers diving into functions of UHRF1 ubiquitin ligase activity. Here, a connection to the support of 5mC maintenance in regions of low CpG density. These same regions are prone to 5mC loss in cancer. A potential mechanistic link to PMD formation. #epigenetics
UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
Abstract. The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement throu
academic.oup.com
December 1, 2024 at 3:13 PM
Excited to share the first of 2 new papers diving into functions of UHRF1 ubiquitin ligase activity. Here, a connection to the support of 5mC maintenance in regions of low CpG density. These same regions are prone to 5mC loss in cancer. A potential mechanistic link to PMD formation. #epigenetics
Reposted by Scott Rothbart
The VAI @vainstitute.bsky.social Graduate School is recruiting Ph.D. students in molecular & cell biology! Get top-tier scientific training, mentorship, and prep for leadership in biomedical research. 🎓 Watch our recruiting video: youtu.be/cOTdF06MekE #PhDSky #BioMedSky
Van Andel Institute Graduate School
YouTube video by Van Andel Institute
youtu.be
November 21, 2024 at 4:03 PM
The VAI @vainstitute.bsky.social Graduate School is recruiting Ph.D. students in molecular & cell biology! Get top-tier scientific training, mentorship, and prep for leadership in biomedical research. 🎓 Watch our recruiting video: youtu.be/cOTdF06MekE #PhDSky #BioMedSky
Reposted by Scott Rothbart
Our institute is hiring for a new faculty to join my department at any level! Incredible research support, a great community, a chance to build something while still being at a place already producing top tier research. We start reviewing apps in 2 weeks! vai.wd1.myworkdayjobs.com/en-US/VAICar...
Faculty Position in Metabolism and Nutritional Programming
Van Andel Institute (VAI), a world-class biomedical research institute, located in Grand Rapids, Michigan, is dedicated to improving human health. We are pioneers in the fight against cancer, Parkinso...
vai.wd1.myworkdayjobs.com
November 15, 2024 at 11:12 AM
Our institute is hiring for a new faculty to join my department at any level! Incredible research support, a great community, a chance to build something while still being at a place already producing top tier research. We start reviewing apps in 2 weeks! vai.wd1.myworkdayjobs.com/en-US/VAICar...
Reposted by Scott Rothbart
VAI scientists have identified more than 1,000 previously undetected proteins in common metabolite samples. In a new Nature Communications paper, they offer a novel protocol for removing them to improve metabolomics results:
www.vai.org/article/stud...
www.vai.org/article/stud...
Study finds persistent proteins may influence metabolomics results
The findings in the Mass Spec Core at Van Andel Institute, published in Nature Communications, give scientists new insights and tools for improving future metabolomics experiments, including a novel p...
www.vai.org
July 17, 2024 at 5:06 PM
VAI scientists have identified more than 1,000 previously undetected proteins in common metabolite samples. In a new Nature Communications paper, they offer a novel protocol for removing them to improve metabolomics results:
www.vai.org/article/stud...
www.vai.org/article/stud...
We had a fun lab lunch today celebrating recent acceptances of 2 papers and a new grant! Details to follow. Proud of this team and their accomplishments. #epigenetics
November 13, 2024 at 10:05 PM
We had a fun lab lunch today celebrating recent acceptances of 2 papers and a new grant! Details to follow. Proud of this team and their accomplishments. #epigenetics