Rosetta Commons
@rosettacommons.bsky.social
Rosetta Commons is the central hub for hundreds of developers and scientists from ~100 universities and laboratories to contribute and share the Rosetta source code.
Rosetta Commons members develop software improvements to solve their unique queries.
Rosetta Commons members develop software improvements to solve their unique queries.
Pinned
We are very excited to announce that early bird registration for European RosettaCon 2025 is now open!
More information here: europeanrosettacon.org
More information here: europeanrosettacon.org
Science update:
Baker lab introduces NeoNectins, which help the body respond to surgical implants, healing gels, and other biomaterials. The study was led by postdoctoral scholar Xinru Wang, PhD, and visiting researcher Jordi Guillem-Marti, PhD
Quick read: rosettacommons.org/2025/06/26/d...
Baker lab introduces NeoNectins, which help the body respond to surgical implants, healing gels, and other biomaterials. The study was led by postdoctoral scholar Xinru Wang, PhD, and visiting researcher Jordi Guillem-Marti, PhD
Quick read: rosettacommons.org/2025/06/26/d...
August 15, 2025 at 8:59 PM
Science update:
Baker lab introduces NeoNectins, which help the body respond to surgical implants, healing gels, and other biomaterials. The study was led by postdoctoral scholar Xinru Wang, PhD, and visiting researcher Jordi Guillem-Marti, PhD
Quick read: rosettacommons.org/2025/06/26/d...
Baker lab introduces NeoNectins, which help the body respond to surgical implants, healing gels, and other biomaterials. The study was led by postdoctoral scholar Xinru Wang, PhD, and visiting researcher Jordi Guillem-Marti, PhD
Quick read: rosettacommons.org/2025/06/26/d...
We'd like to thank our generous sponsors for making SRC 2025 a successful event. Your support fueled innovation, collaboration, and community.
Our sponsors this year: @vilyatx.bsky.social, Lila Biologics, Merck, NOVOPROTEIN, and @levitate.bio.
Explore these companies and their great work.
Our sponsors this year: @vilyatx.bsky.social, Lila Biologics, Merck, NOVOPROTEIN, and @levitate.bio.
Explore these companies and their great work.
August 8, 2025 at 10:27 PM
We'd like to thank our generous sponsors for making SRC 2025 a successful event. Your support fueled innovation, collaboration, and community.
Our sponsors this year: @vilyatx.bsky.social, Lila Biologics, Merck, NOVOPROTEIN, and @levitate.bio.
Explore these companies and their great work.
Our sponsors this year: @vilyatx.bsky.social, Lila Biologics, Merck, NOVOPROTEIN, and @levitate.bio.
Explore these companies and their great work.
Members of IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of de novo design of macrocyclic peptides that bind proteins with nanomolar affinity and remarkable precision.
Read more: rosettacommons.org/2025/06/26/i...
Read more: rosettacommons.org/2025/06/26/i...
Introducing Deep-Learning–Designed Macrocycles: High-Affinity Protein-Binders
Members of the IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of the de novo design of macrocyclic peptides that bind protei…
rosettacommons.org
August 1, 2025 at 11:47 PM
Members of IPD: Gaurav Bhardwaj, Frank DiMaio, and 2024 Nobel laureate David Baker have unveiled a deep-learning framework capable of de novo design of macrocyclic peptides that bind proteins with nanomolar affinity and remarkable precision.
Read more: rosettacommons.org/2025/06/26/i...
Read more: rosettacommons.org/2025/06/26/i...
Registration for the Biomolecular Modeling and Design with Rosetta and ML Tools Workshop (November 17–19, 2025) is now open. The goal of the workshop is to educate and train academic and industry users on the Rosetta software suite.
Explore more: meilerlab.org/tutorials/
Explore more: meilerlab.org/tutorials/
Tutorials – Meiler Lab
meilerlab.org
July 25, 2025 at 8:53 PM
Registration for the Biomolecular Modeling and Design with Rosetta and ML Tools Workshop (November 17–19, 2025) is now open. The goal of the workshop is to educate and train academic and industry users on the Rosetta software suite.
Explore more: meilerlab.org/tutorials/
Explore more: meilerlab.org/tutorials/
RFdiffusion: Beta Documentation Now Available
We’re excited to announce that RFdiffusion now has official, Rosetta Commons-curated documentation! Read more: rosettacommons.org/2025/07/16/r...
We’re excited to announce that RFdiffusion now has official, Rosetta Commons-curated documentation! Read more: rosettacommons.org/2025/07/16/r...
rosettacommons.org
July 16, 2025 at 3:16 AM
RFdiffusion: Beta Documentation Now Available
We’re excited to announce that RFdiffusion now has official, Rosetta Commons-curated documentation! Read more: rosettacommons.org/2025/07/16/r...
We’re excited to announce that RFdiffusion now has official, Rosetta Commons-curated documentation! Read more: rosettacommons.org/2025/07/16/r...
Reposted by Rosetta Commons
We listened to your feedback. Proscuplt is:
*Easier to install - now uses use containers 🚀
*Easier to run in SLURM - specify queue & task details directly in the prosculpt YAML file.
github.com/ajasja/prosc...
Big thanks to Federico Olivieri, Alina Konstantinova, Nej Bizjak, and Žan Žnidar🙏
*Easier to install - now uses use containers 🚀
*Easier to run in SLURM - specify queue & task details directly in the prosculpt YAML file.
github.com/ajasja/prosc...
Big thanks to Federico Olivieri, Alina Konstantinova, Nej Bizjak, and Žan Žnidar🙏
Release v1.0.0 · ajasja/prosculpt
What's new
Prosculpt now easier to install -- uses containers!
Prosculpt now easier to run on SLURM -- all SLURM (queue, number of tasks) info can be given in the prosculpt yaml file.
What's Chan...
github.com
July 14, 2025 at 2:16 PM
We listened to your feedback. Proscuplt is:
*Easier to install - now uses use containers 🚀
*Easier to run in SLURM - specify queue & task details directly in the prosculpt YAML file.
github.com/ajasja/prosc...
Big thanks to Federico Olivieri, Alina Konstantinova, Nej Bizjak, and Žan Žnidar🙏
*Easier to install - now uses use containers 🚀
*Easier to run in SLURM - specify queue & task details directly in the prosculpt YAML file.
github.com/ajasja/prosc...
Big thanks to Federico Olivieri, Alina Konstantinova, Nej Bizjak, and Žan Žnidar🙏
We’re making a few intentional changes to our US-based Rosetta conferences next year to better support our growing community. We want to hear what you think.
Learn more about the changes: rosettacommons.org/2025/06/26/l...
Share your thoughts: docs.google.com/forms/d/e/1F...
Learn more about the changes: rosettacommons.org/2025/06/26/l...
Share your thoughts: docs.google.com/forms/d/e/1F...
Looking Ahead: What’s Changing for RosettaCons in 2026
As the Rosetta Commons community continues to grow, the Executive Board has been actively rethinking how we plan and structure our annual gatherings. The goal is to create events that are more sust…
rosettacommons.org
July 14, 2025 at 4:18 PM
We’re making a few intentional changes to our US-based Rosetta conferences next year to better support our growing community. We want to hear what you think.
Learn more about the changes: rosettacommons.org/2025/06/26/l...
Share your thoughts: docs.google.com/forms/d/e/1F...
Learn more about the changes: rosettacommons.org/2025/06/26/l...
Share your thoughts: docs.google.com/forms/d/e/1F...
RC Biosecurity Fellowship is accepting proposals: 12-month program offers a chance to shape how protein design tools are developed & governed. Fellows lead initiatives, engage with our labs & policy experts, & help bridge science and policy around biosecurity.
rosettacommons.org/2025/06/26/r...
rosettacommons.org/2025/06/26/r...
Rosetta Commons Opens Applications for 2025 Biosecurity Fellow
Rosetta Commons is now accepting applications for our next Biosecurity Fellow! This unique 12-month fellowship offers the opportunity to work at the intersection of computational protein design and…
rosettacommons.org
July 11, 2025 at 11:37 PM
RC Biosecurity Fellowship is accepting proposals: 12-month program offers a chance to shape how protein design tools are developed & governed. Fellows lead initiatives, engage with our labs & policy experts, & help bridge science and policy around biosecurity.
rosettacommons.org/2025/06/26/r...
rosettacommons.org/2025/06/26/r...
News from the Rosetta community: Prosculpt – an open-source library integrating RFDiffusion, ProteinMPNN, AlphaFold2 & Rosetta into one easy workflow
More via @ajasjaljubetic.bsky.social : rosettacommons.org/2025/05/28/a...
More via @ajasjaljubetic.bsky.social : rosettacommons.org/2025/05/28/a...
All about Prosculpt
by Ajasja Ljubetic Prosculpt is an open-source library that encapsulates RFDiffusion, ProteinMPNN, AlphaFold2, and Rosetta into an easy-to-use workflow. The input is a yaml file describing the prob…
rosettacommons.org
June 30, 2025 at 8:53 PM
News from the Rosetta community: Prosculpt – an open-source library integrating RFDiffusion, ProteinMPNN, AlphaFold2 & Rosetta into one easy workflow
More via @ajasjaljubetic.bsky.social : rosettacommons.org/2025/05/28/a...
More via @ajasjaljubetic.bsky.social : rosettacommons.org/2025/05/28/a...
We are very excited to announce that early bird registration for European RosettaCon 2025 is now open!
More information here: europeanrosettacon.org
More information here: europeanrosettacon.org
June 30, 2025 at 1:56 PM
We are very excited to announce that early bird registration for European RosettaCon 2025 is now open!
More information here: europeanrosettacon.org
More information here: europeanrosettacon.org
Reposted by Rosetta Commons
Early bird registration for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓 is open! 🎉🎉🎉
Come join us for three days of protein design fun! (October 20-22, 2025)
Direct registration link: pretix.eu/SBD/RCon2025/
Website: europeanrosettacon.org
We are looking forward to seeing you!
Please share this far and wide:)
Come join us for three days of protein design fun! (October 20-22, 2025)
Direct registration link: pretix.eu/SBD/RCon2025/
Website: europeanrosettacon.org
We are looking forward to seeing you!
Please share this far and wide:)
June 26, 2025 at 4:30 PM
Early bird registration for 𝐄𝐔 𝐑𝐨𝐬𝐞𝐭𝐭𝐚 𝐂𝐨𝐧 𝟐𝟎𝟐𝟓 is open! 🎉🎉🎉
Come join us for three days of protein design fun! (October 20-22, 2025)
Direct registration link: pretix.eu/SBD/RCon2025/
Website: europeanrosettacon.org
We are looking forward to seeing you!
Please share this far and wide:)
Come join us for three days of protein design fun! (October 20-22, 2025)
Direct registration link: pretix.eu/SBD/RCon2025/
Website: europeanrosettacon.org
We are looking forward to seeing you!
Please share this far and wide:)
Summer RosettaCon 2025 registration will close this Sunday, June 1, at 11:59 PM EDT. Register now on RosettaCon.org.
This year, we have a new panel format for our talks, covering protein design with Rosetta and deep learning, as well as other modeling topics you're interested in, and much more!
This year, we have a new panel format for our talks, covering protein design with Rosetta and deep learning, as well as other modeling topics you're interested in, and much more!
Summer Rosetta Con
RosettaCon.org
June 26, 2025 at 3:18 PM
Summer RosettaCon 2025 registration will close this Sunday, June 1, at 11:59 PM EDT. Register now on RosettaCon.org.
This year, we have a new panel format for our talks, covering protein design with Rosetta and deep learning, as well as other modeling topics you're interested in, and much more!
This year, we have a new panel format for our talks, covering protein design with Rosetta and deep learning, as well as other modeling topics you're interested in, and much more!
Our Rosetta Commons Research Experience for Undergraduates (REU) students have completed the first leg of the program with the @jeffreyjgray.bsky.social lab at the Johns Hopkins University and are now heading to their host labs for the summer. Stay tuned for more!
June 20, 2025 at 6:21 PM
Our Rosetta Commons Research Experience for Undergraduates (REU) students have completed the first leg of the program with the @jeffreyjgray.bsky.social lab at the Johns Hopkins University and are now heading to their host labs for the summer. Stay tuned for more!
How to train your model.
This immersive, hands-on, advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design. Join us for this Summer RosettaCon 2025 workshop/hackathon, more here: rosettacommons.org/2025/05/30/h...
This immersive, hands-on, advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design. Join us for this Summer RosettaCon 2025 workshop/hackathon, more here: rosettacommons.org/2025/05/30/h...
How to train your model
An advanced protein design Bootcamp / Hackathon software developer event Summer RosettaCon 2025 – Bootcamp / Hackathon – Application is open, apply here This immersive, hands-on event i…
rosettacommons.org
June 9, 2025 at 3:35 PM
How to train your model.
This immersive, hands-on, advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design. Join us for this Summer RosettaCon 2025 workshop/hackathon, more here: rosettacommons.org/2025/05/30/h...
This immersive, hands-on, advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design. Join us for this Summer RosettaCon 2025 workshop/hackathon, more here: rosettacommons.org/2025/05/30/h...
Consider joining us for the SRC2025's 1-day Protein Design: One-day novice-level course surveying popular tools and workflows for modern protein design with brief exploration of common applications including antibody design and binder design. rosettacommons.org/2025/06/03/1-day-protein-design/
1-day Protein Design
AI-Driven Design of Biologics: Hands-on Guide to Using State-of-the-Art ML Protein Models brought to you by the Rosetta Commons Summer RosettaCon 2025 Workshop. Applications are now open, apply her…
rosettacommons.org
June 6, 2025 at 8:34 PM
Consider joining us for the SRC2025's 1-day Protein Design: One-day novice-level course surveying popular tools and workflows for modern protein design with brief exploration of common applications including antibody design and binder design. rosettacommons.org/2025/06/03/1-day-protein-design/
One-day novice-level course surveying popular tools and workflow for modern protein design with brief exploration of common applications including antibody design and binder design: 1-day Protein Design Workshop. Register here: tinyurl.com/SRC25-worksh...
1-day Protein Design Workshop @ SRC 2025
AI-Driven Design of Biologics: Hands-on Guide to Using State-of-the-Art ML Protein Models brought to you by the Rosetta Commons Event dates Sunday 8/3 1pm - 6 pm Monday 8/4 8am - 2 pm Event Locati...
tinyurl.com
May 21, 2025 at 7:37 PM
One-day novice-level course surveying popular tools and workflow for modern protein design with brief exploration of common applications including antibody design and binder design: 1-day Protein Design Workshop. Register here: tinyurl.com/SRC25-worksh...
Register for SRC25 Workshop (tinyurl.com/SRC25-worksh...) : How to train your model - This immersive, hands-on advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design.
How to train your model
Event dates Sunday 8/3 1pm - 10pm Monday 8/4 7am - 2pm Friday 8/8 9am-10pm Saturday 8/9 Travel Application Link This immersive, hands-on event is designed for researchers who are ready to move beyo...
tinyurl.com
May 21, 2025 at 7:35 PM
Register for SRC25 Workshop (tinyurl.com/SRC25-worksh...) : How to train your model - This immersive, hands-on advanced-level event is designed for researchers who are ready to move beyond “out-of-the-box” machine learning models for protein design.
Come hang out with us — Registration for Summer RosettaCon 2025 is open! It will be held at Suncadia Resort in Washington from August 4 - 7, 2025. Register here: rosettacon.org
Summer Rosetta Con
rosettacon.org
May 21, 2025 at 7:26 PM
Come hang out with us — Registration for Summer RosettaCon 2025 is open! It will be held at Suncadia Resort in Washington from August 4 - 7, 2025. Register here: rosettacon.org
Our team is growing! We are delighted to share the addition of two new members to the Open Rosetta team at OMSF. Please join us in welcoming Rachel Clune, Ph.D. as our new Documentation Writer and Hope Woods as our new Technical Product Lead.
Read more: rosettacommons.org/2025/05/15/w...
Read more: rosettacommons.org/2025/05/15/w...
Welcome Rachel Clune and Hope Woods to the Open Rosetta Team!
We are delighted to share the addition of two new members to the Open Rosetta team at OMSF. Please join us in welcoming Rachel Clune as our new Documentation Writer, starting on May 1, and Hope Woo…
rosettacommons.org
May 19, 2025 at 4:40 PM
Our team is growing! We are delighted to share the addition of two new members to the Open Rosetta team at OMSF. Please join us in welcoming Rachel Clune, Ph.D. as our new Documentation Writer and Hope Woods as our new Technical Product Lead.
Read more: rosettacommons.org/2025/05/15/w...
Read more: rosettacommons.org/2025/05/15/w...
We are pleased to announce that Summer RosettaCon 2025 will take place at Suncadia Resort in Washington from August 4 to 7, 2025. Registration is now open: rosettacon.org/registration/
Find details here: rosettacommons.org/2025/04/20/s...
We look forward to seeing you there!
Find details here: rosettacommons.org/2025/04/20/s...
We look forward to seeing you there!
Summer RosettaCon 2025 – Registration open!
We are pleased to announce that Summer RosettaCon 2025 will take place at Suncadia Resort in Washington from August 4 to 7, 2025. Registration is now open! The conference will start in the late aft…
rosettacommons.org
April 21, 2025 at 10:20 PM
We are pleased to announce that Summer RosettaCon 2025 will take place at Suncadia Resort in Washington from August 4 to 7, 2025. Registration is now open: rosettacon.org/registration/
Find details here: rosettacommons.org/2025/04/20/s...
We look forward to seeing you there!
Find details here: rosettacommons.org/2025/04/20/s...
We look forward to seeing you there!
We received 613 applications—and now we’re proud to welcome 23 students to the 2025 Rosetta Commons REU! Read more about what they have to tell you about themselves and highlight their goals and interests:
🔗 rosettacommons.org/2025/04/11/i...
🔗 rosettacommons.org/2025/04/11/i...
Introducing Rosetta Commons Research Experience for Undergraduates (REU) 2025
We’re pleased to introduce the 2025 Rosetta Commons Research Experience for Undergraduates (REU) cohort. Interns in this REU program, which is hosted across multiple locations, engage in research u…
rosettacommons.org
April 14, 2025 at 2:12 PM
We received 613 applications—and now we’re proud to welcome 23 students to the 2025 Rosetta Commons REU! Read more about what they have to tell you about themselves and highlight their goals and interests:
🔗 rosettacommons.org/2025/04/11/i...
🔗 rosettacommons.org/2025/04/11/i...
Announcing the new RC AlphaRed container designer to run AlphaRed. AlphaFold-initiated replica exchange protein docking is a pipeline to predict protein complex structures from sequences. Read more: github.com/Graylab/Alph...
GitHub - Graylab/AlphaRED: AlphaFold-initiated replica exchange protein docking
AlphaFold-initiated replica exchange protein docking - Graylab/AlphaRED
github.com
April 7, 2025 at 5:56 PM
Announcing the new RC AlphaRed container designer to run AlphaRed. AlphaFold-initiated replica exchange protein docking is a pipeline to predict protein complex structures from sequences. Read more: github.com/Graylab/Alph...
Save the date: Summer RosettaCon 2025 will happen from Aug 4-7, 2025 in Cle Elum! Registration opening soon
New for 2025: SRC will feature thematic scientific panels (not individual submissions). If you're interested in organizing or joining a panel, please sign up here: tinyurl.com/SRC25-Panels
New for 2025: SRC will feature thematic scientific panels (not individual submissions). If you're interested in organizing or joining a panel, please sign up here: tinyurl.com/SRC25-Panels
April 7, 2025 at 4:28 PM
Save the date: Summer RosettaCon 2025 will happen from Aug 4-7, 2025 in Cle Elum! Registration opening soon
New for 2025: SRC will feature thematic scientific panels (not individual submissions). If you're interested in organizing or joining a panel, please sign up here: tinyurl.com/SRC25-Panels
New for 2025: SRC will feature thematic scientific panels (not individual submissions). If you're interested in organizing or joining a panel, please sign up here: tinyurl.com/SRC25-Panels
Winter RosettaCon 2025 brought together a community of 335 participants. The scientific organizers Anum Glasgow and Sergey Ovchinnikov created a program featuring 40 talks, showcasing research from academia, industry, and external participants.
Read more rosettacommons.org/2025/03/20/w...
Read more rosettacommons.org/2025/03/20/w...
March 20, 2025 at 7:53 PM
Winter RosettaCon 2025 brought together a community of 335 participants. The scientific organizers Anum Glasgow and Sergey Ovchinnikov created a program featuring 40 talks, showcasing research from academia, industry, and external participants.
Read more rosettacommons.org/2025/03/20/w...
Read more rosettacommons.org/2025/03/20/w...