Jonas Meisner
@rosemeis.bsky.social
Assistant Professor
NNF Center for Basic Metabolic Research
University of Copenhagen
https://github.com/Rosemeis
NNF Center for Basic Metabolic Research
University of Copenhagen
https://github.com/Rosemeis
January 7, 2025 at 11:13 AM
Please have a look at the paper and the software! I have just released a new and faster version of *hapla*, and I'm excited about the potential future applications of the inferred haplotype clusters.
January 7, 2025 at 10:05 AM
Please have a look at the paper and the software! I have just released a new and faster version of *hapla*, and I'm excited about the potential future applications of the inferred haplotype clusters.
We further find that reference-based PRSs computed from large-scale GWAS summary statistics on depression and schizophrenia are highly correlated with estimated principal components in the iPSYCH cohort, thus, indicating residual confounding due to population structure in the GWASs.
January 7, 2025 at 10:05 AM
We further find that reference-based PRSs computed from large-scale GWAS summary statistics on depression and schizophrenia are highly correlated with estimated principal components in the iPSYCH cohort, thus, indicating residual confounding due to population structure in the GWASs.
We show that we can utilize inferred haplotype clusters to compute more accurate heritability estimates and reference-free polygenic scores compared to standard genotype-based approaches in extensive simulations and the iPSYCH cohort for depression and schizophrenia disorders.
January 7, 2025 at 10:05 AM
We show that we can utilize inferred haplotype clusters to compute more accurate heritability estimates and reference-free polygenic scores compared to standard genotype-based approaches in extensive simulations and the iPSYCH cohort for depression and schizophrenia disorders.