Roselyne Chauvin
@roselynechauvin.bsky.social
Post doc at DosenbachLab, Washington university in st louis.
previously Donders Institute
- Task & Rest fMRI - children development - brain plasticity
CogniJunior founder/illustrator - OHBM com committee
previously Donders Institute
- Task & Rest fMRI - children development - brain plasticity
CogniJunior founder/illustrator - OHBM com committee
Pulses and increased FC overlap with specific task motor execution thalamic nuclei: VIM, VPL (Ventro posterior lateral) and CM (centromedian)
April 12, 2025 at 5:59 PM
Pulses and increased FC overlap with specific task motor execution thalamic nuclei: VIM, VPL (Ventro posterior lateral) and CM (centromedian)
Such disuse pulses were detectable for all participants in the thalamus. They propagate from cortex to thalamus and cerebellum, where pulses peak with a time delay.
April 12, 2025 at 5:59 PM
Such disuse pulses were detectable for all participants in the thalamus. They propagate from cortex to thalamus and cerebellum, where pulses peak with a time delay.
This suggests a potential overlap between limb disuse during casting and Parkinson’s disease.
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting (Newbold et al., Neuron 2020)
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting (Newbold et al., Neuron 2020)
April 12, 2025 at 5:59 PM
This suggests a potential overlap between limb disuse during casting and Parkinson’s disease.
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting (Newbold et al., Neuron 2020)
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting (Newbold et al., Neuron 2020)
Interestingly, this increase in motor circuit FC can also be found in Parkinson’s Disease. An effect that contrasts with other neurodegenerative diseases in which FC decreases overall. (see pubmed.ncbi.nlm.nih.gov/29878081/)
April 12, 2025 at 5:59 PM
Interestingly, this increase in motor circuit FC can also be found in Parkinson’s Disease. An effect that contrasts with other neurodegenerative diseases in which FC decreases overall. (see pubmed.ncbi.nlm.nih.gov/29878081/)
During casting, the motor cortex region of the disused hand & arm increased functional connectivity (FC) with the posterior putamen and the thalamus. The effect size was very large! Cohen’s d >0.8 (up to 3.4!).
April 12, 2025 at 5:59 PM
During casting, the motor cortex region of the disused hand & arm increased functional connectivity (FC) with the posterior putamen and the thalamus. The effect size was very large! Cohen’s d >0.8 (up to 3.4!).
We used high quality data with more than 20h of resting state per individual. On top of that, they spend 2 weeks with a casted arm to see their motor circuit plasticity.
You might know the dataset: www.cell.com/neuron/pdfEx... www.pnas.org/doi/10.1073/...
You might know the dataset: www.cell.com/neuron/pdfEx... www.pnas.org/doi/10.1073/...
April 12, 2025 at 5:59 PM
We used high quality data with more than 20h of resting state per individual. On top of that, they spend 2 weeks with a casted arm to see their motor circuit plasticity.
You might know the dataset: www.cell.com/neuron/pdfEx... www.pnas.org/doi/10.1073/...
You might know the dataset: www.cell.com/neuron/pdfEx... www.pnas.org/doi/10.1073/...
Knowing more can help us treat better, but studying the subcortex in humans with fMRI is a challenge due to signal drop (fig source: pubmed.ncbi.nlm.nih.gov/33741307/)
April 12, 2025 at 5:59 PM
Knowing more can help us treat better, but studying the subcortex in humans with fMRI is a challenge due to signal drop (fig source: pubmed.ncbi.nlm.nih.gov/33741307/)
We know that cortico-striato-thalamo-cortical loops are very important for motor adaptation, as they control movement execution, habit formation and reward-based learning. (see www.nature.com/articles/nrn... )
April 12, 2025 at 5:59 PM
We know that cortico-striato-thalamo-cortical loops are very important for motor adaptation, as they control movement execution, habit formation and reward-based learning. (see www.nature.com/articles/nrn... )
All our participants showed large effect in thalamic nuclei important for Parkinson’s treatment and sleep regulation.
Similarities with findings observed in #Parkinson’s Disease and #sleep, hint at the larger implications of these findings. Let me unfold it
Similarities with findings observed in #Parkinson’s Disease and #sleep, hint at the larger implications of these findings. Let me unfold it
April 12, 2025 at 5:59 PM
All our participants showed large effect in thalamic nuclei important for Parkinson’s treatment and sleep regulation.
Similarities with findings observed in #Parkinson’s Disease and #sleep, hint at the larger implications of these findings. Let me unfold it
Similarities with findings observed in #Parkinson’s Disease and #sleep, hint at the larger implications of these findings. Let me unfold it
During arm immobilization by casting, the motor circuit that controls the disused arm displays increased connectivity and spontaneous activity pulses that affect deep cortical regions (putamen, thalamus) important for motor plasticity.
April 12, 2025 at 5:59 PM
During arm immobilization by casting, the motor circuit that controls the disused arm displays increased connectivity and spontaneous activity pulses that affect deep cortical regions (putamen, thalamus) important for motor plasticity.
It turns out the brain🧠is silently🤫working when your arm is in a cast. 🩼 🚧
Plastic changes occur, and revert again when the cast is removed … not just in cortex.
Plastic changes occur, and revert again when the cast is removed … not just in cortex.
April 12, 2025 at 5:59 PM
It turns out the brain🧠is silently🤫working when your arm is in a cast. 🩼 🚧
Plastic changes occur, and revert again when the cast is removed … not just in cortex.
Plastic changes occur, and revert again when the cast is removed … not just in cortex.
And, in bonus, if you need material to talk about Parkinson's disease to a younger audience, here is a little comic that I made few years ago for Donders Wonders blog at Donders Institute with my non-profit Cogni'Junior
January 26, 2024 at 8:17 PM
And, in bonus, if you need material to talk about Parkinson's disease to a younger audience, here is a little comic that I made few years ago for Donders Wonders blog at Donders Institute with my non-profit Cogni'Junior
Pulses and increased FC overlap with specific task motor execution thalamic nuclei : VIM, VPL (ventro posterior lateral) and CM (centromedian)
January 26, 2024 at 8:14 PM
Pulses and increased FC overlap with specific task motor execution thalamic nuclei : VIM, VPL (ventro posterior lateral) and CM (centromedian)
Such disuse pulses were detectable for all participants in thalamus. They propagate from cortex to thalamus and cerebellum, where pulse peaks with a delay.
January 26, 2024 at 8:13 PM
Such disuse pulses were detectable for all participants in thalamus. They propagate from cortex to thalamus and cerebellum, where pulse peaks with a delay.
This suggests a shared pathophysiology between limb disuse during casting and Parkinson’s disease.
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting
January 26, 2024 at 8:13 PM
This suggests a shared pathophysiology between limb disuse during casting and Parkinson’s disease.
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting
But that’s not all what we learned from this new investigation. We previously showed the emergence of motor cortex spontaneous pulses during casting
Interestingly, this increase in motor circuit FC also an effect that can be found in Parkinson’s disease patient data. An effect that contrasts with other neurodegenerative diseases in which FC decreases overall. (see pubmed.ncbi.nlm.nih.gov/29878081/ )
January 26, 2024 at 8:12 PM
Interestingly, this increase in motor circuit FC also an effect that can be found in Parkinson’s disease patient data. An effect that contrasts with other neurodegenerative diseases in which FC decreases overall. (see pubmed.ncbi.nlm.nih.gov/29878081/ )
We performed analyses sensitive to subcortical signal characteristics
During casting, the motor cortex region of the disused hand increases functional connectivity with the posterior putamen and the thalamus. The effect size was similar to other FC changes within the cortex or with the cerebellum.
During casting, the motor cortex region of the disused hand increases functional connectivity with the posterior putamen and the thalamus. The effect size was similar to other FC changes within the cortex or with the cerebellum.
January 26, 2024 at 8:12 PM
We performed analyses sensitive to subcortical signal characteristics
During casting, the motor cortex region of the disused hand increases functional connectivity with the posterior putamen and the thalamus. The effect size was similar to other FC changes within the cortex or with the cerebellum.
During casting, the motor cortex region of the disused hand increases functional connectivity with the posterior putamen and the thalamus. The effect size was similar to other FC changes within the cortex or with the cerebellum.
We used high quality data with more than 20h of resting state within individuals. On top of that, they spend 2 weeks with a casted arm to see their motor circuit plasticity.
You might know the dataset: www.cell.com/neuron/pdfEx...
You might know the dataset: www.cell.com/neuron/pdfEx...
January 26, 2024 at 8:10 PM
We used high quality data with more than 20h of resting state within individuals. On top of that, they spend 2 weeks with a casted arm to see their motor circuit plasticity.
You might know the dataset: www.cell.com/neuron/pdfEx...
You might know the dataset: www.cell.com/neuron/pdfEx...
Knowing more to treat better is important but it is a challenge to study the subcortex in humans with fMRI, due to signal drop (fig source: pubmed.ncbi.nlm.nih.gov/33741307/)
January 26, 2024 at 8:10 PM
Knowing more to treat better is important but it is a challenge to study the subcortex in humans with fMRI, due to signal drop (fig source: pubmed.ncbi.nlm.nih.gov/33741307/)
We know that cortico-striato-thalamo-cortical loops are very important for motor adaptation, as they control movement execution, habit formation and reward-based learning. (Fig source www.nature.com/articles/s41... )
January 26, 2024 at 8:06 PM
We know that cortico-striato-thalamo-cortical loops are very important for motor adaptation, as they control movement execution, habit formation and reward-based learning. (Fig source www.nature.com/articles/s41... )
How to find massive motor plasticity effects in the subcortex? Find out in our preprint. www.biorxiv.org/content/10.1... Turns out these new findings change our understanding of #Parkinson disease and some #sleep processes.
January 26, 2024 at 8:02 PM
How to find massive motor plasticity effects in the subcortex? Find out in our preprint. www.biorxiv.org/content/10.1... Turns out these new findings change our understanding of #Parkinson disease and some #sleep processes.
Après 2 ans de travail avec les membres de Cogni'Junior, lundi à 17h (+1GMT) sortira notre première vidéo tuto du kit OCEANA (enseigner les neurosciences appliquées a l'éducation). Venez la voir en live. youtu.be/rrpVYJp4ASY
Puis ce sera une par mois pour l'ensemble des 18 de la séries
Puis ce sera une par mois pour l'ensemble des 18 de la séries
November 10, 2023 at 5:41 PM
Après 2 ans de travail avec les membres de Cogni'Junior, lundi à 17h (+1GMT) sortira notre première vidéo tuto du kit OCEANA (enseigner les neurosciences appliquées a l'éducation). Venez la voir en live. youtu.be/rrpVYJp4ASY
Puis ce sera une par mois pour l'ensemble des 18 de la séries
Puis ce sera une par mois pour l'ensemble des 18 de la séries