Here, we illustrated a regulatory pathway connecting common and rare variants associated with heart valve development. This provides a model in which common genetic variation tunes the severity or form of CHD, potentially explaining the varying severities of heart defects in CHD patients carrying th

For example, we found enhancers with spatially specific activity in either the outflow tract or interventricular septum. This suggests a means by which noncoding genetic variants can affect specific aspects of heart structure.

VICs and cardiac fibroblasts were strongly implicated in multiple CHD subtypes. This suggests that heart defects may arise from issues beyond the working myocardium, motivating the development of appropriate cell and animal models to study the contributions of these cell types to CHD.

First, we collected single-cell multiomic data from 734K single cells from 41 fetal hearts spanning post-conception weeks 6 to 22 and annotated them to over 90 different cell types and cell states, including rare and clinically relevant ones like cardiac conduction cells.

Here, we illustrated a regulatory pathway connecting common and rare variants associated with heart valve development. This provides a model in which common genetic variation tunes the severity or form of CHD, potentially explaining the varying severities of heart defects in CHD patients carrying th

For example, we found enhancers with spatially specific activity in either the outflow tract or interventricular septum. This suggests a means by which noncoding genetic variants can affect specific aspects of heart structure.

VICs and cardiac fibroblasts were strongly implicated in multiple CHD subtypes. This suggests that heart defects may arise from issues beyond the working myocardium, motivating the development of appropriate cell and animal models to study the contributions of these cell types to CHD.

First, we collected single-cell multiomic data from 734K single cells from 41 fetal hearts spanning post-conception weeks 6 to 22 and annotated them to over 90 different cell types and cell states, including rare and clinically relevant ones like cardiac conduction cells.