Ronja Houtekamer
@ronjahoutekamer.bsky.social
PhD candidate @Gloerich lab @UMCU, studying the role of mechanical forces in epithelial homeostasis. Fascinated by the interplay between mechanics, stem cells and signaling.
Phosphoproteomics and transcriptomics of stretched epithelial monolayers revealed that mechanical strain activates EGFR-ERK signaling via E-cadherin mechanotransduction. How? Intercellular forces transduced by E-cadherin trigger ADAM-mediated shedding of EGFR ligands that drive downstream signaling.
September 13, 2025 at 6:05 PM
Phosphoproteomics and transcriptomics of stretched epithelial monolayers revealed that mechanical strain activates EGFR-ERK signaling via E-cadherin mechanotransduction. How? Intercellular forces transduced by E-cadherin trigger ADAM-mediated shedding of EGFR ligands that drive downstream signaling.