Ron Beavis ❌
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ronbeavis.mastodon.social.ap.brid.gy
Ron Beavis ❌
@ronbeavis.mastodon.social.ap.brid.gy
Doing science for money since 1981.
Putting it online since 1995.
Just say no to cancer research (lesson learned).
QA >> QC
I enjoy doing things I am not very good […]

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Any PUZZLE domain that flanks (i.e., is adjacent to) a structured domain is now officially a FUZZLE domain.
November 17, 2025 at 1:17 PM
I would very much appreciate anyone who could provide me with an existing way to refer to the two proximal flanking IDRs associated with a named functional domain because I don't know of any such terminology.
November 15, 2025 at 1:36 PM
Another key finding from structural biology is that eukaryotes have not developed an S, T or Y kinase that can modify an alpha helix or a beta strand. There are kinases that can modify residues in IDRs immediately adjacent to these secondary structures, but the structures themselves remain pristine.
November 13, 2025 at 3:07 PM
Put another way, one of the key findings of structural biology is that many protein biological functions are performed by sequence regions without rigid secondary or tertiary structure.
November 12, 2025 at 4:54 PM
While ANKRD11:p may not be top of the pops in the proteomics world, it does have a broad, significant role as a transcription-associated controller even though it eschews the notions key to "structural biology".
https://onlinelibrary.wiley.com/doi/10.1111/cge.13977
November 12, 2025 at 1:49 PM
Can anyone from the protein-protein/protein-nucleic-acid binding world identify what those 2 big ankyrin repeat domains are clamping themselves onto?
November 11, 2025 at 4:25 PM