Rommie Amaro
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rommieamaro.bsky.social
Rommie Amaro
@rommieamaro.bsky.social
4.5K followers 630 following 330 posts
Professor at UC San Diego. Computational biophysics, biology, chemistry. Multiscale modeler. Viruses. Cancer. Co-Director of the Airborne Institute.
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rommieamaro.bsky.social
✨✨ It's #glycotime for #HIV Env ✨✨

N-linked glycans modulate flexibility & MPER epitope exposure #glycotime

Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪

Would love feedback!

www.biorxiv.org/content/10.1...
March 28, 2025 at 4:23 AM
rommieamaro.bsky.social
✨ Check out @mackevinbraza.bsky.social 's new work on full length APOBEC3B, which shows how the NTD modulates active site opening in the CTD

Collab w/ @adaozlemdemir.bsky.social & Aihara, Herzik, & Harris labs

pubs.acs.org/doi/10.1021/...
March 26, 2025 at 3:21 PM
rommieamaro.bsky.social
interesting preprint from Weria Pezeshkian on general material properties of membranes

Lateral tension can lead to membrane neck constriction at low tension & dilation at high tensions

relevant to nuclear pores, ER, mitochondria, Golgi etc

www.biorxiv.org/content/10.1...
Visualisation of the necks‘ behaviour for six (right) necks in PBC at bending rigidity of 𝜅 = 10 𝑘𝐵𝑇. This illustrates a second transition point or region in the six-neck-system, facilitated by successive dilation of more than one neck.
March 14, 2025 at 4:52 PM
rommieamaro.bsky.social
A behemoth effort from @fionachembot.bsky.social in which she does amazing science (showing how VOCs reshape allosteric pathways) while also making the SARS2 spike color palette match her fish Dorry 😍🫠
www.biorxiv.org/content/10.1...
spike protein domains and mutations in VOCs Fiona's tang fish named Dorry matches the spike colors
March 13, 2025 at 4:38 AM
rommieamaro.bsky.social
☀️ Stand Up for Science 🧪

@ucsandiego.bsky.social
March 7, 2025 at 10:05 PM
rommieamaro.bsky.social
From my NIH SRO:

MSFA postponed.
The February 25 - 26, 2025 meeting of the Molecular Structure and Function A (MSFA) study section has been postponed. I do not have any information on when it might be rescheduled. The goal is for all applications to be reviewed at a future date to be determined. Your application will remain in the system until such time as it is able to be reviewed.
February 24, 2025 at 9:37 PM
rommieamaro.bsky.social
More cuts to NIH & apparently folks who stay dealing with stuff like this. They don't even make enough to put up with such nonsense!

Please hang in there NIH, NSF, & other federal folks! We're so grateful for all you do ❤️‍🩹

www.science.org/content/arti...
picture of tweet from Elon Musk stating "Consistent with President Trump's instructions, all federal employees will shortly receive an email requesting to understand what they got done last week. Failure to respond will be taken as a resignation."
February 22, 2025 at 10:03 PM
rommieamaro.bsky.social
Attorneys general argue that the NIH’s new policy violates the Administrative Procedure Act

& ignores congressional powers by retroactively modifying existing contracts that set IDC rate between the federal government & research institutions

www.statnews.com/2025/02/10/n...
February 10, 2025 at 5:33 PM
rommieamaro.bsky.social
Look at THIS!!! ❤️😂
@amjjbonvin.bsky.social
Beer from Brno
December 25, 2024 at 9:13 PM
rommieamaro.bsky.social
Big fan of your work but this influenza picture keeps showing up & it's structurally incorrect- NA has a stalk that makes it nearly as tall as HA, it doesn't sit on top of the membrane like that, even if the stalk has a deletion
Structure of influenza virion showing NA with its proper stalk
December 18, 2024 at 6:29 PM
rommieamaro.bsky.social
New cryoEM structure of zoonotic H5N1 from Peter Kwong's lab curiously shows the glycan at N169 occupying the HA receptor binding site of a neighboring promoter #glycotime 🧪

www.biorxiv.org/content/10.1...
image from Kwong preprint showing HA structure with N169 glycan occupying receptor binding site on neighboring promoter
December 9, 2024 at 5:57 PM
rommieamaro.bsky.social
@dereklowe.bsky.social honing in on the same bottom line message from @wpwalters.bsky.social @prof-ajay-jain.bsky.social

it's so true and hits so hard:
quotation of preprint from Jain, Cleaves, and Walters about hype vs reality in computer aided drug design, highlights by Lowe
December 6, 2024 at 8:57 PM
rommieamaro.bsky.social
A project 10 years in the making w/ Terry Sejnowski, led by
@philosophaki.bsky.social

Insights into ryanodine receptor activation & calcium-induced Ca2+ release from a stochastic explicit-particle 3D simulation of cardiac dyad w/ realistic TEM geometry 🧪

www.sciencedirect.com/science/arti...
November 26, 2024 at 2:39 PM
rommieamaro.bsky.social
A project 10 years in the making w/ Terry Sejnowski, led by @philosophaki.bsky.social

Insights into ryanodine receptor activation & calcium-induced Ca2+ release from a stochastic explicit-particle 3D simulation of cardiac dyad w/ realistic geometry (from TEM)

www.sciencedirect.com/science/arti...
November 26, 2024 at 2:01 PM
rommieamaro.bsky.social
With the news of the patient in BC, I'm starting to worry now about the pretty one in the bottom middle... 😬 (image by Abby Dommer)
images of viruses
November 16, 2024 at 6:29 PM