Roberto Díaz-Peña
@roberdp.bsky.social
PhD, PI Immunogenetics: Immunogenomics/Autoimmunity/Rheumatology/Oncology/Bioinformatics.
Reposted by Roberto Díaz-Peña
Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)
February 6, 2025 at 11:09 AM
Introducing a major upgrade to OmicsPred platform (www.omicspred.org) — a resource to enhance the accessibility and usability of genetic scores for multi-omic traits and their phenotypic associations. (1/N)
Reposted by Roberto Díaz-Peña
Perspective @corp4s.bsky.social
Bridging genomics’ greatest challenge: The diversity gap
www.cell.com/cell-genomic...
Bridging genomics’ greatest challenge: The diversity gap
www.cell.com/cell-genomic...
December 17, 2024 at 5:45 PM
Perspective @corp4s.bsky.social
Bridging genomics’ greatest challenge: The diversity gap
www.cell.com/cell-genomic...
Bridging genomics’ greatest challenge: The diversity gap
www.cell.com/cell-genomic...
Reposted by Roberto Díaz-Peña
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Specificity, length, and luck: How genes are prioritized by rare and common variant association studies
Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...
www.biorxiv.org
December 17, 2024 at 7:05 AM
What do GWAS and rare variant burden tests discover, and why?
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Do these studies find the most IMPORTANT genes? If not, how DO they rank genes?
Here we present a surprising result: these studies actually test for SPECIFICITY! A 🧵on what this means... (🧪🧬)
www.biorxiv.org/content/10.1...
Reposted by Roberto Díaz-Peña
Happy to share our new collaborative work! 🚨 We analyzed 2250 TCR repertoires to uncover how HLA risk alleles shape immune autoreactivity in T1D. T1D-specific HLA-motifs were also validated in pancreatic lymph nodes (pLN) & spleen. 🧬🧵 #T1D #Immunology #TCR 1/9
December 14, 2024 at 11:05 AM
Happy to share our new collaborative work! 🚨 We analyzed 2250 TCR repertoires to uncover how HLA risk alleles shape immune autoreactivity in T1D. T1D-specific HLA-motifs were also validated in pancreatic lymph nodes (pLN) & spleen. 🧬🧵 #T1D #Immunology #TCR 1/9
Reposted by Roberto Díaz-Peña
Instarted making a list the other day, with the help of others adding their own faves: github.com/MichelNivard...
GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.
A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics
github.com
December 2, 2024 at 8:57 PM
Instarted making a list the other day, with the help of others adding their own faves: github.com/MichelNivard...