Kevin Roarty
@roartylab.bsky.social
Assistant Professor at Baylor College of Medicine | Breast Cancer Researcher | Scientist, Mentor, Husband, and Girl Dad of Two. roartylab.org
🚨 New preprint alert! 🚨
Wnt/Ror2 signaling stabilizes basal epithelial identity. Using lineage tracing, we show that Ror2 loss disrupts mechanotransduction (RhoA-ROCK1-YAP1) and chromatin accessibility, driving a basal-to-luminal transition in the mammary gland.
🔗: www.biorxiv.org/content/10.1...
Wnt/Ror2 signaling stabilizes basal epithelial identity. Using lineage tracing, we show that Ror2 loss disrupts mechanotransduction (RhoA-ROCK1-YAP1) and chromatin accessibility, driving a basal-to-luminal transition in the mammary gland.
🔗: www.biorxiv.org/content/10.1...
Noncanonical Wnt/Ror2 Signaling Regulates Basal Cell Fidelity and Branching Morphogenesis in the Mammary Gland
The mammary gland epithelium relies on a delicate balance between basal and luminal cell lineages to maintain tissue homeostasis and enable proper development. While the role of canonical Wnt signalin...
www.biorxiv.org
February 25, 2025 at 10:32 PM
🚨 New preprint alert! 🚨
Wnt/Ror2 signaling stabilizes basal epithelial identity. Using lineage tracing, we show that Ror2 loss disrupts mechanotransduction (RhoA-ROCK1-YAP1) and chromatin accessibility, driving a basal-to-luminal transition in the mammary gland.
🔗: www.biorxiv.org/content/10.1...
Wnt/Ror2 signaling stabilizes basal epithelial identity. Using lineage tracing, we show that Ror2 loss disrupts mechanotransduction (RhoA-ROCK1-YAP1) and chromatin accessibility, driving a basal-to-luminal transition in the mammary gland.
🔗: www.biorxiv.org/content/10.1...