In fact, it would only take an unmeasured confounder with a HR =0.9 and a 0.2 SD difference in means to tip this result. See
tipr::tip_hr_with_continuous(effect_observed = .98, exposure_confounder_effect = .2)
tipr::tip_hr_with_continuous(effect_observed = .98, exposure_confounder_effect = .2)
October 16, 2025 at 2:32 PM
In fact, it would only take an unmeasured confounder with a HR =0.9 and a 0.2 SD difference in means to tip this result. See
tipr::tip_hr_with_continuous(effect_observed = .98, exposure_confounder_effect = .2)
tipr::tip_hr_with_continuous(effect_observed = .98, exposure_confounder_effect = .2)
Sorry, pointing to early separation in prior RCTs does not reassure me that there is no residual confounding in this weighted analysis of observational data. Also sad to see the BMJ hyping the 11% number, failing to point out that (if we believe estimates) the data is consistent with a 2% difference
October 16, 2025 at 2:28 PM
Sorry, pointing to early separation in prior RCTs does not reassure me that there is no residual confounding in this weighted analysis of observational data. Also sad to see the BMJ hyping the 11% number, failing to point out that (if we believe estimates) the data is consistent with a 2% difference
These are trials? If you'd like me to be more verbose: this kind of early separation in curves in an observational study using PS methods to try and eliminate confounding is most likely due to residual confounding
October 16, 2025 at 2:02 PM
These are trials? If you'd like me to be more verbose: this kind of early separation in curves in an observational study using PS methods to try and eliminate confounding is most likely due to residual confounding
Curves separate immediately which is a clear sign of residual confounding
October 16, 2025 at 10:14 AM
Curves separate immediately which is a clear sign of residual confounding
Well unfortunately people are going to do observational studies where RCTs raise ethical issues (e.g. pregnancy). Not having subject matter experts involved increases the chance of bias. Obviously possible for an epidemiologist to gain expertise but probably easier to collaborate
September 27, 2025 at 12:10 PM
Well unfortunately people are going to do observational studies where RCTs raise ethical issues (e.g. pregnancy). Not having subject matter experts involved increases the chance of bias. Obviously possible for an epidemiologist to gain expertise but probably easier to collaborate
Fascinating. So in a situation where you're trying to determine which of two treatments leads to better outcomes, having no idea of how treatment decisions are made would be just fine as long as you have general epi expertise?
September 26, 2025 at 12:28 PM
Fascinating. So in a situation where you're trying to determine which of two treatments leads to better outcomes, having no idea of how treatment decisions are made would be just fine as long as you have general epi expertise?
If you want to understand potential confounding factors domain expertise is vital
September 26, 2025 at 11:28 AM
If you want to understand potential confounding factors domain expertise is vital
What @ezraklein.bsky.social would call "politics the right way". Lol
September 11, 2025 at 11:49 PM
What @ezraklein.bsky.social would call "politics the right way". Lol
If someone walks away from this understanding that bus usage outside London is down roughly 50% whereas in London it has increased roughly 100% in the same period, where have they been misled? Honestly curious
August 22, 2025 at 12:01 AM
If someone walks away from this understanding that bus usage outside London is down roughly 50% whereas in London it has increased roughly 100% in the same period, where have they been misled? Honestly curious
I genuinely don't understand what is misleading about this?
August 21, 2025 at 11:58 PM
I genuinely don't understand what is misleading about this?
It would depend on what kind of spline you are using. If you're doing the analysis in R the rms package has functions for printing the model equation
July 30, 2025 at 1:41 AM
It would depend on what kind of spline you are using. If you're doing the analysis in R the rms package has functions for printing the model equation
It is baffling to me how many senior researchers make blanket statements degrading other's work. Please educate the group and show us a recent simulation study (e.g. in SiM) where you could do "the calculations" (this might involve linking to a paper that is not your own)
July 1, 2025 at 9:53 AM
It is baffling to me how many senior researchers make blanket statements degrading other's work. Please educate the group and show us a recent simulation study (e.g. in SiM) where you could do "the calculations" (this might involve linking to a paper that is not your own)
Wrong link casualinfer.libsyn.com/site/combini...
Casual Inference: Combining Data & Making Effects Generalizable with Carly Brantner | Season 6 Episode 7
Carly Brantner is an assistant professor of Biostatistics & Bioinformatics at Duke University and Duke Clinical Research Institute. Follow along on Bluesky: Carly: Ellie: Lucy: &n...
casualinfer.libsyn.com
June 13, 2025 at 2:24 AM
Wrong link casualinfer.libsyn.com/site/combini...
In R
`Hmisc::getHdata("gusto")`
`Hmisc::getHdata("gusto")`
May 11, 2025 at 2:54 AM
In R
`Hmisc::getHdata("gusto")`
`Hmisc::getHdata("gusto")`
GUSTO-1 is big - see www.fharrell.com/post/path/
Implementation of the PATH Statement – Statistical Thinking
The recent PATH (Predictive Approaches to Treatment effect Heterogeneity) Statement outlines principles, criteria, and key considerations for applying predictive approaches to clinical trials to provi...
www.fharrell.com
May 11, 2025 at 2:51 AM
GUSTO-1 is big - see www.fharrell.com/post/path/
Not sure why one would do both split sample *and* bootstrap for internal validation. Am I missing something?
January 25, 2025 at 2:05 PM
Not sure why one would do both split sample *and* bootstrap for internal validation. Am I missing something?
For those interested in what not to do www.frontiersin.org/journals/car...
January 25, 2025 at 2:02 PM
For those interested in what not to do www.frontiersin.org/journals/car...
Did you just rebrand Master of Health Informatics (MHI) degrees?
January 17, 2025 at 7:42 PM
Did you just rebrand Master of Health Informatics (MHI) degrees?
I agree the terminology is contradictory; the 'inferior' is referring to 0 and the 'non-inferior' is referring to the NI margin. If we have to have NI trials your wording would be much better!
January 6, 2025 at 9:53 PM
I agree the terminology is contradictory; the 'inferior' is referring to 0 and the 'non-inferior' is referring to the NI margin. If we have to have NI trials your wording would be much better!
The one word should have really been 'inconclusive'
January 6, 2025 at 7:28 PM
The one word should have really been 'inconclusive'