Rishi Gupta
@rishigupta.bsky.social
Respiratory physician, NIHR advanced fellow, UCL-TB, UCL Respiratory
Reposted by Rishi Gupta
Check out our new paper in @lancetmicrobe.bsky.social
In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB
They perform consistently across settings + show potential clinical utility to stratify therapy
#IDsky #TBsky
bit.ly/47jU7GN
In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB
They perform consistently across settings + show potential clinical utility to stratify therapy
#IDsky #TBsky
bit.ly/47jU7GN
Single-gene transcripts for subclinical tuberculosis: an individual participant data meta-analysis
Single-gene transcripts are equivalent to multi-gene signatures for detection of subclinical
tuberculosis, with consistent performance across settings. Single-gene transcripts
show potential clinical ...
bit.ly
October 14, 2025 at 11:31 AM
Check out our new paper in @lancetmicrobe.bsky.social
In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB
They perform consistently across settings + show potential clinical utility to stratify therapy
#IDsky #TBsky
bit.ly/47jU7GN
In this IPD-MA we show that single-gene transcripts are equivalent to multi-gene signatures to Dx subclinical TB
They perform consistently across settings + show potential clinical utility to stratify therapy
#IDsky #TBsky
bit.ly/47jU7GN
Reposted by Rishi Gupta
Interested in the immunopathology of human tuberculosis? Here is our latest review:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Immunopathology in human tuberculosis
The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.
www.science.org
December 13, 2024 at 10:59 PM
Interested in the immunopathology of human tuberculosis? Here is our latest review:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
This was a fun analysis. We started out thinking blood RNA biomarkers of viral infection were likely to be correlated ++ as different dimensions of a common immune response (tinyurl.com/5ebfhsyj)
BUT the sampling resolution of human challenge helped us unravel the time course... IFI27 is unique ⬇️
BUT the sampling resolution of human challenge helped us unravel the time course... IFI27 is unique ⬇️
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications
It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...
www.nature.com
December 11, 2024 at 3:47 PM
This was a fun analysis. We started out thinking blood RNA biomarkers of viral infection were likely to be correlated ++ as different dimensions of a common immune response (tinyurl.com/5ebfhsyj)
BUT the sampling resolution of human challenge helped us unravel the time course... IFI27 is unique ⬇️
BUT the sampling resolution of human challenge helped us unravel the time course... IFI27 is unique ⬇️
Reposted by Rishi Gupta
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...
SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications
It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...
www.nature.com
November 30, 2024 at 2:50 PM
Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...