RheumMadness
@rheummadness.bsky.social
The place for everyone who is crazy about rheumatology to connect, collaborate, compete, and learn together. Now on #Rheumsky!
Learn more here: https://sites.duke.edu/rheummadness/
Learn more here: https://sites.duke.edu/rheummadness/
The final results of #RheumMadness 2025 are out!
Read more about the panel's choices on our website, plus our list of thank you-s to all our collaborators who make this possible!
sites.duke.edu/rheummadness/
Thank you all for another great year!
Read more about the panel's choices on our website, plus our list of thank you-s to all our collaborators who make this possible!
sites.duke.edu/rheummadness/
Thank you all for another great year!
April 7, 2025 at 4:16 PM
The final results of #RheumMadness 2025 are out!
Read more about the panel's choices on our website, plus our list of thank you-s to all our collaborators who make this possible!
sites.duke.edu/rheummadness/
Thank you all for another great year!
Read more about the panel's choices on our website, plus our list of thank you-s to all our collaborators who make this possible!
sites.duke.edu/rheummadness/
Thank you all for another great year!
Round 3 of #RheumMadness is complete!
Read how the Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
How's your bracket?
Read how the Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
How's your bracket?
April 5, 2025 at 3:22 PM
Round 3 of #RheumMadness is complete!
Read how the Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
How's your bracket?
Read how the Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
How's your bracket?
Results from round 2 of #RheumMadness 2025 are out!
Read more about how our Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
Read more about how our Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
April 3, 2025 at 2:00 PM
Results from round 2 of #RheumMadness 2025 are out!
Read more about how our Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
Read more about how our Blue Ribbon Panel voted here:
sites.duke.edu/rheummadness/
#RheumMadness Round 1 Results are in!
We had 3 blowouts and one MASSIVE upset.
Read a full report of the Blue Ribbon Panel's votes and justifications here:
sites.duke.edu/rheummadness/
Round 2 results coming April 3
We had 3 blowouts and one MASSIVE upset.
Read a full report of the Blue Ribbon Panel's votes and justifications here:
sites.duke.edu/rheummadness/
Round 2 results coming April 3
April 1, 2025 at 11:40 AM
#RheumMadness Round 1 Results are in!
We had 3 blowouts and one MASSIVE upset.
Read a full report of the Blue Ribbon Panel's votes and justifications here:
sites.duke.edu/rheummadness/
Round 2 results coming April 3
We had 3 blowouts and one MASSIVE upset.
Read a full report of the Blue Ribbon Panel's votes and justifications here:
sites.duke.edu/rheummadness/
Round 2 results coming April 3
⏳THREE HOURS LEFT⌛️
Submit your #RheumMadness bracket before 11:59pm ET!!!
Submit here:
www.tourneytopia.com/RheumMadness...
Submit your #RheumMadness bracket before 11:59pm ET!!!
Submit here:
www.tourneytopia.com/RheumMadness...
April 1, 2025 at 12:32 AM
⏳THREE HOURS LEFT⌛️
Submit your #RheumMadness bracket before 11:59pm ET!!!
Submit here:
www.tourneytopia.com/RheumMadness...
Submit your #RheumMadness bracket before 11:59pm ET!!!
Submit here:
www.tourneytopia.com/RheumMadness...
Never played #RheumMadness ?
Think you don't have enough time to submit your bracket?
Think again. Submit with two simple steps:
1. Watch the 2-minute explainer video below
2. Head over to the tournament website and submit a bracket (IT'S FREE)
26.5 hours left!
tourneytopia.com/RheumMadness...
Think you don't have enough time to submit your bracket?
Think again. Submit with two simple steps:
1. Watch the 2-minute explainer video below
2. Head over to the tournament website and submit a bracket (IT'S FREE)
26.5 hours left!
tourneytopia.com/RheumMadness...
March 31, 2025 at 1:29 AM
Never played #RheumMadness ?
Think you don't have enough time to submit your bracket?
Think again. Submit with two simple steps:
1. Watch the 2-minute explainer video below
2. Head over to the tournament website and submit a bracket (IT'S FREE)
26.5 hours left!
tourneytopia.com/RheumMadness...
Think you don't have enough time to submit your bracket?
Think again. Submit with two simple steps:
1. Watch the 2-minute explainer video below
2. Head over to the tournament website and submit a bracket (IT'S FREE)
26.5 hours left!
tourneytopia.com/RheumMadness...
The #RheumMadness countdown continues!
Next up: the long-term extension of the TULIP trials, showing long-term safety and efficacy of anifrolumab in #lupus
Scouting report by the MUSC fellows
More in 🧵👇
1/
Next up: the long-term extension of the TULIP trials, showing long-term safety and efficacy of anifrolumab in #lupus
Scouting report by the MUSC fellows
More in 🧵👇
1/
March 27, 2025 at 11:34 AM
The #RheumMadness countdown continues!
Next up: the long-term extension of the TULIP trials, showing long-term safety and efficacy of anifrolumab in #lupus
Scouting report by the MUSC fellows
More in 🧵👇
1/
Next up: the long-term extension of the TULIP trials, showing long-term safety and efficacy of anifrolumab in #lupus
Scouting report by the MUSC fellows
More in 🧵👇
1/
The #RheumMadness countdown continues. Brackets due March 31 at 11:59pm!
Next up, oral biologics! Specifically oral anti-IL23.
@larneson.bsky.social @davidleverenz.bsky.social
1/
Next up, oral biologics! Specifically oral anti-IL23.
@larneson.bsky.social @davidleverenz.bsky.social
1/
March 26, 2025 at 12:28 PM
The #RheumMadness countdown continues. Brackets due March 31 at 11:59pm!
Next up, oral biologics! Specifically oral anti-IL23.
@larneson.bsky.social @davidleverenz.bsky.social
1/
Next up, oral biologics! Specifically oral anti-IL23.
@larneson.bsky.social @davidleverenz.bsky.social
1/
As the #RheumMadness countdown continues, take a BiTE out of this thread!
Introducing BiTE therapy, by Marwin Groener and @maxkonigmd.bsky.social at Hopkins rheum.
1/
Introducing BiTE therapy, by Marwin Groener and @maxkonigmd.bsky.social at Hopkins rheum.
1/
March 26, 2025 at 12:52 AM
As the #RheumMadness countdown continues, take a BiTE out of this thread!
Introducing BiTE therapy, by Marwin Groener and @maxkonigmd.bsky.social at Hopkins rheum.
1/
Introducing BiTE therapy, by Marwin Groener and @maxkonigmd.bsky.social at Hopkins rheum.
1/
APIPPRA also followed patients for 12 months AFTER STOPPING ABATACEPT, and treated patients still had benefit!
Said another way: it's possible ABA in the pre-clinical phase PREVENTED FULL RA.
As the kids say: Big, if true.
5/12
Said another way: it's possible ABA in the pre-clinical phase PREVENTED FULL RA.
As the kids say: Big, if true.
5/12
March 25, 2025 at 12:34 AM
APIPPRA also followed patients for 12 months AFTER STOPPING ABATACEPT, and treated patients still had benefit!
Said another way: it's possible ABA in the pre-clinical phase PREVENTED FULL RA.
As the kids say: Big, if true.
5/12
Said another way: it's possible ABA in the pre-clinical phase PREVENTED FULL RA.
As the kids say: Big, if true.
5/12
Time for another #RheumMadness countdown thread!
Introducing Abatacept in pre-RA, aka the "tendon ticklers" from Allegheny Rheum, based on the APIPPRA trial
Learn more in 🧵👇 (1/12)
Introducing Abatacept in pre-RA, aka the "tendon ticklers" from Allegheny Rheum, based on the APIPPRA trial
Learn more in 🧵👇 (1/12)
March 25, 2025 at 12:34 AM
Time for another #RheumMadness countdown thread!
Introducing Abatacept in pre-RA, aka the "tendon ticklers" from Allegheny Rheum, based on the APIPPRA trial
Learn more in 🧵👇 (1/12)
Introducing Abatacept in pre-RA, aka the "tendon ticklers" from Allegheny Rheum, based on the APIPPRA trial
Learn more in 🧵👇 (1/12)
nd there's even more hope for #Sjogren's with lots of amazing therapies on the horizon!
Check out this brief editorial by Dr. St. Clair (1st author of DAZ study) to learn more:
acrjournals.onlinelibrary.wiley.com/doi/abs/10.1...
11/15
Check out this brief editorial by Dr. St. Clair (1st author of DAZ study) to learn more:
acrjournals.onlinelibrary.wiley.com/doi/abs/10.1...
11/15
March 21, 2025 at 2:22 PM
nd there's even more hope for #Sjogren's with lots of amazing therapies on the horizon!
Check out this brief editorial by Dr. St. Clair (1st author of DAZ study) to learn more:
acrjournals.onlinelibrary.wiley.com/doi/abs/10.1...
11/15
Check out this brief editorial by Dr. St. Clair (1st author of DAZ study) to learn more:
acrjournals.onlinelibrary.wiley.com/doi/abs/10.1...
11/15
Quick reminder of how abatacept works: it's CTLA4 bound to the Fc of an IgG.
CTLA4 is a molecule we already have that blocks CD28-CD80/86 (B7) interactions.
CTLA means T cells Can't Take it Any Longer (Get it? rearrange the first letters?)
8/15
CTLA4 is a molecule we already have that blocks CD28-CD80/86 (B7) interactions.
CTLA means T cells Can't Take it Any Longer (Get it? rearrange the first letters?)
8/15
March 21, 2025 at 2:22 PM
Quick reminder of how abatacept works: it's CTLA4 bound to the Fc of an IgG.
CTLA4 is a molecule we already have that blocks CD28-CD80/86 (B7) interactions.
CTLA means T cells Can't Take it Any Longer (Get it? rearrange the first letters?)
8/15
CTLA4 is a molecule we already have that blocks CD28-CD80/86 (B7) interactions.
CTLA means T cells Can't Take it Any Longer (Get it? rearrange the first letters?)
8/15
This is DIFFERENT than the CD28 co-stimulatory pathway most #rheumatologists are familiar with because we use abatacept (CTLA4-Ig).
CD28-CD80/86 (aka B7) is about APCs ACTIVATING T CELLS
CD40L-CD40 is about T CELLS ACTIVATING OTHER CELLS (like B cells)
7/15
CD28-CD80/86 (aka B7) is about APCs ACTIVATING T CELLS
CD40L-CD40 is about T CELLS ACTIVATING OTHER CELLS (like B cells)
7/15
March 21, 2025 at 2:22 PM
This is DIFFERENT than the CD28 co-stimulatory pathway most #rheumatologists are familiar with because we use abatacept (CTLA4-Ig).
CD28-CD80/86 (aka B7) is about APCs ACTIVATING T CELLS
CD40L-CD40 is about T CELLS ACTIVATING OTHER CELLS (like B cells)
7/15
CD28-CD80/86 (aka B7) is about APCs ACTIVATING T CELLS
CD40L-CD40 is about T CELLS ACTIVATING OTHER CELLS (like B cells)
7/15
So, what is CD40L? It's an important co-stimulatory molecule. Think of it like multi-factor authentication for immune cells. They don't just need a password, they also need a push notification.
For example: CD40L on T cells binds CD40 on B cells, revving them up.
6/15
For example: CD40L on T cells binds CD40 on B cells, revving them up.
6/15
March 21, 2025 at 2:22 PM
So, what is CD40L? It's an important co-stimulatory molecule. Think of it like multi-factor authentication for immune cells. They don't just need a password, they also need a push notification.
For example: CD40L on T cells binds CD40 on B cells, revving them up.
6/15
For example: CD40L on T cells binds CD40 on B cells, revving them up.
6/15
Most importantly, this study is one of the first to demonstrate a strong positive impact on pain, dryness, and fatigue, as defined by high ESSPRI scores.
Cannot overstate how exciting this is!
5/15
Cannot overstate how exciting this is!
5/15
March 21, 2025 at 2:22 PM
Most importantly, this study is one of the first to demonstrate a strong positive impact on pain, dryness, and fatigue, as defined by high ESSPRI scores.
Cannot overstate how exciting this is!
5/15
Cannot overstate how exciting this is!
5/15
This trial showed positive results in patients with high systemic disease activity, as defined by high ESSDAI scores.
But that's been seen before. See next post for the most important finding.
4/15
But that's been seen before. See next post for the most important finding.
4/15
March 21, 2025 at 2:22 PM
This trial showed positive results in patients with high systemic disease activity, as defined by high ESSDAI scores.
But that's been seen before. See next post for the most important finding.
4/15
But that's been seen before. See next post for the most important finding.
4/15
As we count down to #RheumMadness brackets closing (March 31!), it's time for some threads about each team.
First up? The novel CD40L inhibitor in #Sjogren's. Scouting report by #DukeRheum.
More in 🧵👇 (1/15)
First up? The novel CD40L inhibitor in #Sjogren's. Scouting report by #DukeRheum.
More in 🧵👇 (1/15)
March 21, 2025 at 2:22 PM
As we count down to #RheumMadness brackets closing (March 31!), it's time for some threads about each team.
First up? The novel CD40L inhibitor in #Sjogren's. Scouting report by #DukeRheum.
More in 🧵👇 (1/15)
First up? The novel CD40L inhibitor in #Sjogren's. Scouting report by #DukeRheum.
More in 🧵👇 (1/15)
Introducing the 2025 #RheumMadness Blue Ribbon Panel!
@profbeckyg.bsky.social @rheumarhyme.bsky.social
Bracket submissions open until April 1.
Learn more 👇
sites.duke.edu/rheummadness/
@profbeckyg.bsky.social @rheumarhyme.bsky.social
Bracket submissions open until April 1.
Learn more 👇
sites.duke.edu/rheummadness/
March 1, 2025 at 5:18 PM
Introducing the 2025 #RheumMadness Blue Ribbon Panel!
@profbeckyg.bsky.social @rheumarhyme.bsky.social
Bracket submissions open until April 1.
Learn more 👇
sites.duke.edu/rheummadness/
@profbeckyg.bsky.social @rheumarhyme.bsky.social
Bracket submissions open until April 1.
Learn more 👇
sites.duke.edu/rheummadness/
The #RheumMadness podcast has reached >10,000 total downloads!
Apparently, a lot of you are crazy about #Rheumatology.
Apparently, a lot of you are crazy about #Rheumatology.
January 19, 2025 at 3:29 PM
The #RheumMadness podcast has reached >10,000 total downloads!
Apparently, a lot of you are crazy about #Rheumatology.
Apparently, a lot of you are crazy about #Rheumatology.
Another #RheumMadness podcast recording is in the books! This one covered the Full Court Care Champions region, scheduled to be released in February, with many more episodes to be released between now and then!
Thanks to the MCW, WUSTL, and Lankenau teams for joining this one!
Thanks to the MCW, WUSTL, and Lankenau teams for joining this one!
January 9, 2025 at 9:04 PM
Another #RheumMadness podcast recording is in the books! This one covered the Full Court Care Champions region, scheduled to be released in February, with many more episodes to be released between now and then!
Thanks to the MCW, WUSTL, and Lankenau teams for joining this one!
Thanks to the MCW, WUSTL, and Lankenau teams for joining this one!
#RheumMadness 2025 is here!
Scouting reports for the first region (T'd Up T-Cells) have been posted, along with accompanying Q&As from theMednet.org and two new podcast episodes!
Full details 👇
sites.duke.edu/rheummadness/
Scouting reports for the first region (T'd Up T-Cells) have been posted, along with accompanying Q&As from theMednet.org and two new podcast episodes!
Full details 👇
sites.duke.edu/rheummadness/
January 8, 2025 at 11:42 AM
#RheumMadness 2025 is here!
Scouting reports for the first region (T'd Up T-Cells) have been posted, along with accompanying Q&As from theMednet.org and two new podcast episodes!
Full details 👇
sites.duke.edu/rheummadness/
Scouting reports for the first region (T'd Up T-Cells) have been posted, along with accompanying Q&As from theMednet.org and two new podcast episodes!
Full details 👇
sites.duke.edu/rheummadness/