Bonus track: Global signal regression enhances the discovery of synergistic interactions by reducing common sources of redundancy. See also www.nature.com/articles/s42...!

8/9

A systematic comparison: We derived low‑dimensional brain modes using PCA, diffusion maps, Laplacian eigenmodes, Yeo 7 resting‑state network (RSN) averaging, and a nonlinear autoencoder. Each method was constrained to 7 modes, aligning with the 7 @bttyeo.bsky.social RSNs.

6/9

We leverage #informationtheory to detect synergistic high-order interactions in resting‑state #fMRI. Synergistic interactions were consistently present across parcellations with different number of regions, prompting the question: do different DR methods also preserve synergy?

5/9

Dimensionality reduction of brain dynamics should be evaluated not only by reconstruction error or explained variance, but also by whether it preserves key qualitative properties of large-scale dynamics such as synergy.

3/9