Reymond Group
@reymondgroup.bsky.social
Research Group at DCBP UniBern
#Cheminformatics | #PeptideChemistry | #SmallMolecule | #DrugDiscovery | #OrganicSynthesis
#Cheminformatics | #PeptideChemistry | #SmallMolecule | #DrugDiscovery | #OrganicSynthesis
Authors: Aline Carrel, Adonis Yiannakas, Jaap-Jan Roukens, Ines Reynoso-Moreno, @markusorsi.bsky.social, @amolthakkar.bsky.social, Josep Arus-Pous, Daniele Pellegata, Jürg Gertsch, and Jean-Louis Reymond.
@reymondgroup.bsky.social
@reymondgroup.bsky.social
April 25, 2025 at 10:28 AM
Authors: Aline Carrel, Adonis Yiannakas, Jaap-Jan Roukens, Ines Reynoso-Moreno, @markusorsi.bsky.social, @amolthakkar.bsky.social, Josep Arus-Pous, Daniele Pellegata, Jürg Gertsch, and Jean-Louis Reymond.
@reymondgroup.bsky.social
@reymondgroup.bsky.social
Read the full version 👉 onlinelibrary.wiley.com/doi/10.1002/...
In this work, we used a genetic algorithm to design PMB2-like macrocycles with similar antimicrobial activity and lower toxicity, offering a general strategy to explore macrocyclic natural products.
#genetic_algorithm #antimicrobial
In this work, we used a genetic algorithm to design PMB2-like macrocycles with similar antimicrobial activity and lower toxicity, offering a general strategy to explore macrocyclic natural products.
#genetic_algorithm #antimicrobial
Antimicrobial Peptide‐Peptoid Macrocycles from the Polymyxin B2 Chemical Space
We optimized mixed peptide-peptoid sequences for molecular similarity to the macrocyclic lipopeptide antibiotic polymyxin B2 (PMB2) using a genetic algorithm. Synthesis and testing of top-scoring com...
onlinelibrary.wiley.com
April 4, 2025 at 9:11 AM
Read the full version 👉 onlinelibrary.wiley.com/doi/10.1002/...
In this work, we used a genetic algorithm to design PMB2-like macrocycles with similar antimicrobial activity and lower toxicity, offering a general strategy to explore macrocyclic natural products.
#genetic_algorithm #antimicrobial
In this work, we used a genetic algorithm to design PMB2-like macrocycles with similar antimicrobial activity and lower toxicity, offering a general strategy to explore macrocyclic natural products.
#genetic_algorithm #antimicrobial