Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!

Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...

We're so excited to share our newest ancient DNA findings on hunter-gatherers and pastoralists in Kazakhstan!

www.science.org/doi/10.1126/...

Two intensive sampling periods of oyster-associated vibrio and their phage, 4 years apart, and many surprises. Despite being washed by the Atlantic, wide tides, and vibrio (almost?) disappearing most of the year, we can find the exact same virulent phages 4 years later (down to 0 SNP)! preprint👇

Phages evolve fast, or do they?
In oysters, some stay identical for years.
With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements.
Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵

Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.

doi.org/10.1101/2024...

Interested in learning more about how researchers analyze ancient DNA? Here you can find the free lectures from the SPAAM Summer School 2025 - Introduction to Ancient Metagenomics: tinyurl.com/3u9mhmd2
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM

I am still wrapping my head around the amazing week that I had first at our @spaam-community.bsky.social conference #SPAAM7 followed by 3 days of @isba11.bsky.social in Torino.
A conference that ended with a prestigious award. I am very grateful and honoured @isbarchaeology.bsky.social

Oh boy - we opened this year’s ISBA meetings in a Roman amphitheater!

The Warinner Group and collaborators having fun at ISBA11 in Torino, Italy!

Very happy to see this one out: doi.org/10.1093/molbev/msaf192
Here, we assessed the contribution of natural transformation to the acquisition of novel genes. See preprint thread. @molbioevol.bsky.social #microsky #evobio

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

I learned today that the NSF SBE conference I’m co-organizing in DC in eleven days has been cancelled. This seems to be related to he return of DOGE at the NSF: www.science.org/content/arti...

Phage satellites are now known to be very diverse, numerous and ancient. They pose many evolutionary, ecological and mechanistic questions. Lots of fun in perspective!
Great pleasure to write this review to show it, with @jrpenades.bsky.social @dbikard.bsky.social Kim Seed & John Chen.

🚀 Excited to share our new paper: taxMyPhage: Automated Taxonomy of dsDNA Phage Genomes at the Genus and Species Level 🦠🔬!

Big thanks to all collaborators, especially @milja001.bsky.social & Thomas Sicheritz-Pontén! 🙌

📄 www.liebertpub.com/doi/10.1089/...

New version of DefenseFinder available defensefinder.mdmlab.fr (& cli)

Now encompassing 263 systems (+111 this year..!).

Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models

Check out our new research in NPJ Biofilms and Microbiomes on the surprising patterns of oral streptococci variation in humans and the clues they encode for understanding human evolution and the recent impacts of oral hygiene. A big congratulations to Irina Velsko! www.nature.com/articles/s41...

And another big study from our lab out this month on exploring the potential of dental calculus to shed light on past human migrations! A huge thank you to all of our collaborators throughout Oceania and Island Southeast Asia who made this research possible! www.nature.com/articles/s41...