Regula Furrer
@regula-furrer.bsky.social
Scientist at the Biozentrum, University of Basel, Switzerland | Molecular Exercise Physiology | Muscle Plasticity | Aging | Cachexia | Exercise is Medicine
Reposted by Regula Furrer
If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
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doi.org/10.1101/2025...
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doi.org/10.1101/2025...
Muscle Fiber- and Cell Type-Specificity of Training Adaptation in Male Mice
Skeletal muscle possesses extraordinary plasticity of structure, metabolism, and function in response to repeated contractile activity. As a syncytium embedded within a complex microenvironment, muscl...
doi.org
November 14, 2025 at 2:34 PM
If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.
2/3
doi.org/10.1101/2025...
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doi.org/10.1101/2025...
Reposted by Regula Furrer
... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:
doi.org/10.1038/s415...
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doi.org/10.1038/s415...
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Biomarkers of aging: functional aspects still trump molecular parameters - npj Aging
Biomarkers of aging are indispensable for testing interventions. While promising, the recent focus on molecular aspects should not detract from the functional parameters for which excellent correlatio...
doi.org
March 3, 2025 at 2:15 PM
... gait speed. Still better than anything molecular biomarkers can provide. Our commentary (with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch) out now in NPJ Aging:
doi.org/10.1038/s415...
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doi.org/10.1038/s415...
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Reposted by Regula Furrer
... human cohorts only exist for physiological and functional biomarkers. Thus, if you want to know your "biological age", measure VO2max, muscle/grip strength/power, body composition (muscle mass, fat mass and distribution), leisure time physical activity, and, at advanced age,...
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March 3, 2025 at 2:15 PM
... human cohorts only exist for physiological and functional biomarkers. Thus, if you want to know your "biological age", measure VO2max, muscle/grip strength/power, body composition (muscle mass, fat mass and distribution), leisure time physical activity, and, at advanced age,...
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Reposted by Regula Furrer
BTW, if you want more background information/reading for any of these papers, I shamelessly plug “The molecular athlete: exercise physiology from mechanisms to medals” by @regula-furrer.bsky.social, John Hawley and me (@c-handschin.bsky.social).
journals.physiology.org/doi/full/10....
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journals.physiology.org/doi/full/10....
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The molecular athlete: exercise physiology from mechanisms to medals | Physiological Reviews
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external stimuli including the habitual level of contractile loading. Accordingly, muscle function and exercise capacity ...
journals.physiology.org
January 30, 2025 at 7:33 AM
BTW, if you want more background information/reading for any of these papers, I shamelessly plug “The molecular athlete: exercise physiology from mechanisms to medals” by @regula-furrer.bsky.social, John Hawley and me (@c-handschin.bsky.social).
journals.physiology.org/doi/full/10....
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journals.physiology.org/doi/full/10....
17/17
Reposted by Regula Furrer
“Molecular aspects of the exercise response and training adaptation in skeletal muscle” by @regula-furrer.bsky.social and yours truly (@c-handschin.bsky.social).
www.sciencedirect.com/science/arti...
6/17
www.sciencedirect.com/science/arti...
6/17
Molecular aspects of the exercise response and training adaptation in skeletal muscle
Skeletal muscle plasticity enables an enormous potential to adapt to various internal and external stimuli and perturbations. Most notably, changes in…
www.sciencedirect.com
January 30, 2025 at 7:33 AM
“Molecular aspects of the exercise response and training adaptation in skeletal muscle” by @regula-furrer.bsky.social and yours truly (@c-handschin.bsky.social).
www.sciencedirect.com/science/arti...
6/17
www.sciencedirect.com/science/arti...
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