Very excited to present OpenCGChromatin🔥🔥🔥

A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation

Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups

To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social

María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social

Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social

Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social

Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social

Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social

Who's going to #BPS2025?

Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC

Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more

Please repost! 🚀✨

We’re hiring! 🚨

We’re looking for motivated postdocs to join our team and help us advance the frontiers of chromatin simulations

Learn more and apply here: www.jobs.cam.ac.uk/job/50052/

Women and underrepresented profiles in STEM are encouraged to apply

Please repost to help us spread the word!

What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties?

We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)

Happy holidays from the Collepardo group ♥️

Is chromatin ordered or disordered? It all depends on the linker DNA length.

Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets