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ratpappi.bsky.social
🐀 ⚕ RatPappi ⚕ 🐀
@ratpappi.bsky.social
330 followers 540 following 600 posts
24 | 🏳️‍⚧️ He/It/They | Demi/Bi | WA | 🐀🩸⨺⃝🩸🐀
Digital artist, Disabled, Phlebotomist, Body mod enthusiast. Lover of all things silly and macabre!
Married: @lexinss.bsky.social 💖💍
OCs, Fanart, Comms, lots of reskeets! 🔞
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ratpappi.bsky.social
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August 5, 2025 at 2:59 AM
ratpappi.bsky.social
Nonononono don’t drag me back down into my special interest 😭 the novel is sitting on my desk rn and I haven’t drawn phanart in a fat min (still on the brain always tho)
August 4, 2025 at 7:26 AM
Reposted by 🐀 ⚕ RatPappi ⚕ 🐀
sailorrooscout.bsky.social
This method of vaccine delivery is effective because the areas of gum between the teeth are highly permeable, allowing them to absorb vaccine molecules easily.

The study has been published in Nature Biomedical Engineering. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
ABSTRACT The oral cavity is an accessible site for vaccination, but its sublingual and buccal sites have limited vaccine uptake. Here we show that flat tape dental floss can deliver vaccines through the junctional epithelium of the gingival sulcus, exploiting its naturally leaky properties. Floss-based vaccination delivered protein, inactivated virus, peptide-presenting immunogenic nanoparticles and messenger RNA. In mice, gold nanoparticles functionalized with a peptide derived from the ectodomain of the transmembrane matrix 2 protein of human influenza virus stimulated local lymph nodes, increased CD4+T cells in lymph nodes, lungs and spleen, and boosted antibody-secreting cells in the bone marrow. Floss-based immunization induced strong and sustained immune activation across multiple organs, robust systemic and mucosal antibody responses, and durable protection against lethal influenza infection, independent of age, food and liquid consumption. Floss-based vaccination was superior to sublingual and comparable with intranasal vaccination. In human participants, fluorescent dye delivered via floss picks effectively reached gingival sulcus, supporting clinical feasibility. These findings establish floss-based vaccination as a simple, needle-free strategy that enhances vaccine delivery and immune activation compared with existing mucosal immunization methods. We acknowledge the support provided by the National Institutes of Health. H.S.G. discloses support for the research described in this study from the National Institutes of Health (grant no. R01AI137846), the National Institutes of Health (grant no. R01DE033759) and the Whitacre Endowed Chair in Science and Engineering. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. We also thank C. Roseburd Magezi Ndamira, a graduate student of Gill lab at TTU, for her help in capturing Supplementary Movie 1.
July 25, 2025 at 4:01 PM