Postscript: for a long time I was very confused about the PDS5-WAPL depletion expts+sims & how extrusion alters compartments. I was fortunate to eventually stumble across @ranjithpa.bsky.social‬'s preprint www.biorxiv.org/content/10.1... & later this by Chan/Rubinstein www.pnas.org/doi/abs/10.1...

Congratulations Ed @irate-physicist.bsky.social on your new work. Look forward to reading it in detail. I missed this thread as I was away from social media for a few days!! Thank you for the comment -- let’s catch up sometime.

We’ve hoped (suspected?) that nondestructive chromatin fiber mapping (pioneered by us & others) captures structural aspects missed by nuclease-based techniques. Here, we keep the tiffin cart rolling w/ IDLI: an approach that infers subnuc-res structure from m6dA long-read footprinting data. (3/n)

Are you in Mumbai?

Congratulations Vijay, Megan @martyyang.bsky.social and everyone in the team!

Cool! Look forward to reading it. Congratulations Ed, Anders and the entire team.