rangachari lab (vijay)
@rangacharilab.bsky.social
disordered proteins, amyloids, biomolecular condensates, soft matter design.
www.rangacharilab.com
Chemistry and Biochemistry, School of Math and Natural Sciences
Center for Molecular and Cellular Biosciences
University of Southern Mississippi
www.rangacharilab.com
Chemistry and Biochemistry, School of Math and Natural Sciences
Center for Molecular and Cellular Biosciences
University of Southern Mississippi
Pinned
Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates
Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and nucleic acids that have emerged as important players in many cellular functions. Uncovering the sequence determinants of...
pubs.acs.org
Sharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...
We are excited to launch the SouthEast Amyloid CONdensate (SEACON) symposium!! Our inaugural meeting will take place in Ocean Springs, MS, in August 2025. For details, please visit:
www.rangacharilab.com/1st-seacon-s...
www.rangacharilab.com/1st-seacon-s...
SEACON Symposium — www.rangacharilab.com
www.rangacharilab.com
June 28, 2025 at 4:16 AM
We are excited to launch the SouthEast Amyloid CONdensate (SEACON) symposium!! Our inaugural meeting will take place in Ocean Springs, MS, in August 2025. For details, please visit:
www.rangacharilab.com/1st-seacon-s...
www.rangacharilab.com/1st-seacon-s...
Excited to share our new data on the use of redox-sensitive peptide condensates as cell delivery vehicles. We show that our peptide condensates can efficiently deliver a variety of small molecules, DNA, mRNA, and proteins, to the cellular cytoplasm.
www.biorxiv.org/content/10.1....
www.biorxiv.org/content/10.1....
Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.
Biomolecular condensates (BCs) are phase-separated viscoelastic hubs within demixed solutions enriched in proteins and nucleic acids. Such condensates, also called membraneless organelles, are increas...
www.biorxiv.org
May 24, 2025 at 1:09 AM
Excited to share our new data on the use of redox-sensitive peptide condensates as cell delivery vehicles. We show that our peptide condensates can efficiently deliver a variety of small molecules, DNA, mRNA, and proteins, to the cellular cytoplasm.
www.biorxiv.org/content/10.1....
www.biorxiv.org/content/10.1....
Excited to share our latest work on amyloid-synthetic polymer blends. pubs.acs.org/doi/10.1021/...
De Novo Amyloid Peptide–Polymer Blends with Enhanced Mechanical and Biological Properties
Amyloid peptides are structurally diverse materials that exhibit different properties depending on their self-assembly. While they are often associated with neurodegenerative diseases, functional amyl...
pubs.acs.org
March 13, 2025 at 3:16 PM
Excited to share our latest work on amyloid-synthetic polymer blends. pubs.acs.org/doi/10.1021/...
Want to know about #IDPs? Why not hear from @rohitpappu68.bsky.social in his typical éloquence royale?
For our first scientific session spotlight we are "Peeking away from the lampost" with Dr. Rohit Pappu as he joins us to discuss intrinsically disordered proteins. @rohitpappu68.bsky.social @biophysicalsoc.bsky.social #bps2025 youtu.be/pAP2lBWBiGU
Intrinsically Disordered Proteins: A Peek Away from the Lampost
YouTube video by WebsEdge Science
youtu.be
February 17, 2025 at 3:23 PM
Want to know about #IDPs? Why not hear from @rohitpappu68.bsky.social in his typical éloquence royale?
Oh am sure every $ spent on $750b military is legit… saving $12b by killing science and bright minds is worth it..
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 2:07 AM
Oh am sure every $ spent on $750b military is legit… saving $12b by killing science and bright minds is worth it..
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Wishing you all a peaceful, healthy, and a prosperous 2025!!
January 1, 2025 at 4:10 PM
Wishing you all a peaceful, healthy, and a prosperous 2025!!
It was fantastic and humbling to receive a personal email from @J_A_C_S, the editor-in-chief, congratulating us on this work. Malay_Moldal and others deserve all the credit.👏
Sharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...
Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates
Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and nucleic acids that have emerged as important players in many cellular functions. Uncovering the sequence determinants of...
pubs.acs.org
December 10, 2024 at 5:14 PM
It was fantastic and humbling to receive a personal email from @J_A_C_S, the editor-in-chief, congratulating us on this work. Malay_Moldal and others deserve all the credit.👏
NEW SOCIETY ALERT! "International Society for Proteinopathies" is a group focused on pathomechanisms of protein-misfolding diseases. If you are interested in protein aggregation and phase transitions, this is for you.
Please come on board with us..
www.proteinopathies.org
Please come on board with us..
www.proteinopathies.org
HOME | proteinopathies.org
www.proteinopathies.org
December 5, 2024 at 1:53 PM
NEW SOCIETY ALERT! "International Society for Proteinopathies" is a group focused on pathomechanisms of protein-misfolding diseases. If you are interested in protein aggregation and phase transitions, this is for you.
Please come on board with us..
www.proteinopathies.org
Please come on board with us..
www.proteinopathies.org
A significant discovery elegantly demonstrated...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
www.nature.com
November 27, 2024 at 8:42 PM
A significant discovery elegantly demonstrated...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Check out our chapter on "Amyloid Polymorphism" in the book "The Three Functional States of Proteins."
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Structural polymorphism in amyloids—states within proteins’ solid-state
Proteins are functionally diverse molecules that exist in a plethora of conformations and structures or as disordered ensembles, depending on their pr…
www.sciencedirect.com
November 25, 2024 at 2:16 PM
Check out our chapter on "Amyloid Polymorphism" in the book "The Three Functional States of Proteins."
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by rangachari lab (vijay)
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
November 18, 2024 at 2:48 PM
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Reposted by rangachari lab (vijay)
Biomolecular condensate starter pack!
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
November 18, 2024 at 9:44 AM
Biomolecular condensate starter pack!
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Trying to compile & to bring together biomolecular condensate enthusiasts & critics!
Please join this non-exhaustive (sorry!) collection & just ping me for addition.
#condensates, #phaseseparation, #granules, #IDPs
go.bsky.app/NFqmffa
Reposted by rangachari lab (vijay)
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
go.bsky.app/J23B51L
November 10, 2024 at 7:38 PM
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
go.bsky.app/J23B51L
Sharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...
Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates
Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and nucleic acids that have emerged as important players in many cellular functions. Uncovering the sequence determinants of...
pubs.acs.org
November 13, 2024 at 2:47 PM
Sharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...
When the tweets are gone, it's time to ❌ the X and flutter to the Bluesky 🦋...
November 13, 2024 at 2:43 PM
When the tweets are gone, it's time to ❌ the X and flutter to the Bluesky 🦋...