Quantum Alchemist
quantum-alchemist.bsky.social
Quantum Alchemist
@quantum-alchemist.bsky.social
Lapsed organic chemist. Core instrumentation lab director. I love science, technology, and ingenious solutions to problems great and small.
What’s the instrument?
March 8, 2025 at 2:31 PM
You could centrifuge again after derivatization, but you might be better off trying to dry in stages to get a small final volume before lyophilization.

In the end, you’re not going to get full recovery, but your istd will account for your losses.
March 7, 2025 at 12:15 PM
The dilution would likely keep the stoichiometry sensible to the extent that it is known. Still, with a small final volume and a large vessel, you’re going to have major losses (assuming those are the losses you’re talking about?).
March 7, 2025 at 12:08 PM
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March 7, 2025 at 8:21 AM
I have a fear that at this rate it may become difficult to get visas for international scholars. The US has been a sought after training ground for scientists from around the world. Many stayed after their training, providing a huge boost to our STEM capabilities. What will that look like by Fall?
March 7, 2025 at 8:16 AM
I suspect you’ll need to provide more experimental detail. Your references aren’t directly great for that either apart from the Shimadzu prep. You’re lyoing 25mL in a 50mL tube vs their 250uL in a 1.5mL tube, but still using the same amount of reagent. Seems like a mismatch in scale.
March 7, 2025 at 8:04 AM
Thank you!
March 1, 2025 at 2:54 PM
Thank you!
March 1, 2025 at 2:54 PM
This is an old list, fry’s electronics went out of business in 2021. Any chance your source has an update?
March 1, 2025 at 1:22 PM
Could be a glass blower’s practice piece for attaching such connections? Erlenmeyer flasks are a cheap substrate.

Or, you know, any of the valid use cases above.
December 19, 2024 at 4:20 AM
Submit AI generated drivel, promise to pay them for the publication as soon as your next grant on that topic comes in.

Someone has to be responding to these invitations for them to keep at it, right? Or is this some kind of avant garde performance art?
December 17, 2024 at 11:12 AM
Syntheses of compounds with fully substituted five membered rings were always interesting to me. Corey’s Ginkolide B is a classic. Johnson’s Pactamycin was one I appreciated.
December 17, 2024 at 3:41 AM
Target compound elutes at 98% B, but you ran a gradient and got great separation. Illusory accomplishment.
December 17, 2024 at 2:44 AM
Alternatively, you fill properly, but the proportioning valve jammed.
December 17, 2024 at 2:43 AM