QMUL Centre for Oral Immunobiology and Regenerative Medicine
@qmul-coirm.bsky.social
We are a collaborative group of academics, clinicians, and researchers in cancer, immunology, microbiology, oral medicine, surgery, periodontology, cell biology, and neurobiology, at the Institute of Dentistry, Queen Mary University of London.
“Our discovery shows how a small molecular tweak can trigger cancer cells to act like cancer stem cells,” explains Prof. Waseem. This finding may offer a powerful way to spot and target these aggressive cells early, paving the way for better diagnosis and treatment. 3/3 #COIRM #cancer
February 14, 2025 at 5:07 PM
This tiny amino acid change disrupts the cell’s structural network, spurs rapid growth, migration, and invasion, and turns cells estrogen-independent in immune-compromised mice. They also found higher levels of a “non-coding” RNA, XIST, and #cancer stem cell markers (CD56, CD20). #ncRNA 2/n
February 14, 2025 at 5:07 PM
Reposted by QMUL Centre for Oral Immunobiology and Regenerative Medicine
The researchers also found that a class of ‘inhibitor’ type drugs – which can block chemical reactions in the body – showed promising results in being able to prevent this damage from occurring. Find out more: www.tandfonline.com/doi/full/10....
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor
The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence ind...
www.tandfonline.com
December 16, 2024 at 2:20 PM
The researchers also found that a class of ‘inhibitor’ type drugs – which can block chemical reactions in the body – showed promising results in being able to prevent this damage from occurring. Find out more: www.tandfonline.com/doi/full/10....
Reposted by QMUL Centre for Oral Immunobiology and Regenerative Medicine
P-cresol sulfate is a molecule produced by the gut microbiome and has been seen to accumulate in the blood of patients with CKD. The study found that the toxin triggers a process which damages the critically protective blood–brain barrier, increasing the risks of strokes and other issues.
December 16, 2024 at 2:20 PM
P-cresol sulfate is a molecule produced by the gut microbiome and has been seen to accumulate in the blood of patients with CKD. The study found that the toxin triggers a process which damages the critically protective blood–brain barrier, increasing the risks of strokes and other issues.