Qiaochu Liang
@qchuliang.bsky.social
Postdoctoral fellow at BC Children's Hospital, University of British Columbia. Goblet cell, mucus, and gut microbes.
We've taken our pathogen-mucus studies from in vivo to in vitro with organoids, revealing how C. rodentium subverts mucus in an ALI model. Even more surprising—we identified a mucinase belonging to Class 1 SPATEs!
New paper from our lab! We developed an organoid-based air-liquid interface (ALI) model that produces physiologically relevant intestinal mucus and discovered that EspC has a mucinolytic superpower which enables C. rodentium to degrade mucus. 🧫🦠https://pmc.ncbi.nlm.nih.gov/articles/PMC12054374/
Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus
Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. F...
pmc.ncbi.nlm.nih.gov
May 9, 2025 at 10:40 PM
We've taken our pathogen-mucus studies from in vivo to in vitro with organoids, revealing how C. rodentium subverts mucus in an ALI model. Even more surprising—we identified a mucinase belonging to Class 1 SPATEs!