Patrick Derksen
@pwbderksen.bsky.social
Preclinical Cancer Biologist. Liberal Humanist. Motorcycle enthousiast. Principal Investigator and Professor @UMCUtrecht, working on #adhesion biology, #metastasis in #ILC #TNBC and #HNSCC. Founder and Chair of the @ELBCC
Afadin is an #ILC #metastasis suppressor! Based on clinical and experimental data we show that Afadin inhibits metastasis by stabilizing the #E-cadherin to F-actin link. The α-catenin binding CC domains is key, not the F-actin binding region! pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...
March 7, 2025 at 7:35 PM
Afadin is an #ILC #metastasis suppressor! Based on clinical and experimental data we show that Afadin inhibits metastasis by stabilizing the #E-cadherin to F-actin link. The α-catenin binding CC domains is key, not the F-actin binding region! pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...