PULAK GHOSH
@pulakghosh23.bsky.social
Pinned
PULAK GHOSH
@pulakghosh23.bsky.social
· Apr 14
Template-independent enzymatic functionalization of DNA oligonucleotides with environment-sensitive nucleotide probes using terminal deoxynucleotidyl transferase
Abstract. Given the emerging use of terminal deoxynucleotidyl transferase (TdT) in biotechnology and its clinical potential as a cancer marker and target,
academic.oup.com
Happy to share that one of my PhD work now in Nucleic Acids Research. We developed a fluorescent technique to detect the TdT activity, which often overexpress in leukemia cell. Grateful to my collaborator and my PhD supervisor Prof. S. G. Srivatsan. @IISER Pune.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Happy to share that one of my PhD work now in Nucleic Acids Research. We developed a fluorescent technique to detect the TdT activity, which often overexpress in leukemia cell. Grateful to my collaborator and my PhD supervisor Prof. S. G. Srivatsan. @IISER Pune.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Template-independent enzymatic functionalization of DNA oligonucleotides with environment-sensitive nucleotide probes using terminal deoxynucleotidyl transferase
Abstract. Given the emerging use of terminal deoxynucleotidyl transferase (TdT) in biotechnology and its clinical potential as a cancer marker and target,
academic.oup.com
April 14, 2025 at 5:15 PM
Happy to share that one of my PhD work now in Nucleic Acids Research. We developed a fluorescent technique to detect the TdT activity, which often overexpress in leukemia cell. Grateful to my collaborator and my PhD supervisor Prof. S. G. Srivatsan. @IISER Pune.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Happy to share our recently published Angew Chem article describing the mechanism of incorporation of modified nucleotides by DNA polymerases using fluorescence, 19F NMR and X-ray. Thanks to my Supervisor Prof.S.G.Srivatsan and congratulations to all authors!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Structures of a DNA Polymerase Caught while Incorporating Responsive Dual‐Functional Nucleotide Probes
Environment-sensitive C5-heterocycle-modified nucleotide probes serve as excellent substrates for Thermus aquaticus DNA polymerase (KlenTaq). The probes provided unprecedent insight into the chemical...
onlinelibrary.wiley.com
November 28, 2024 at 6:41 PM
Happy to share our recently published Angew Chem article describing the mechanism of incorporation of modified nucleotides by DNA polymerases using fluorescence, 19F NMR and X-ray. Thanks to my Supervisor Prof.S.G.Srivatsan and congratulations to all authors!
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...