Gerome Breen
@psychgenomics.bsky.social
Prof Psychiatric Genetics KCL. Lead King's Genomics facility, Genetic Links to Anxiety and Depression (GLAD) Study, and the UK Eating Disorders Genetics Initiative (EDGI-UK). Gratitude to my wonderful research group, staff, and collaborators.
At the #dumpthescales march at Westminster Square in London, met a very purple @vanessalongley.bsky.social from BeatED
June 21, 2025 at 10:32 AM
At the #dumpthescales march at Westminster Square in London, met a very purple @vanessalongley.bsky.social from BeatED
These findings are also present in other psych disorders - panic had the strongest associations overall but schizophrenia and bipolar disorder (particularly) had interesting heart and lung visceral neuron associations.
June 17, 2025 at 10:50 AM
These findings are also present in other psych disorders - panic had the strongest associations overall but schizophrenia and bipolar disorder (particularly) had interesting heart and lung visceral neuron associations.
Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n
June 17, 2025 at 10:50 AM
Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n
Some highlights (for me)
May 26, 2025 at 2:34 PM
Some highlights (for me)
Group poster today from @jaredgm.bsky.social on genetics of perinatal depression. Jared is a DepGenAfrica postdoc - he is looking for collaborators with African PND data also. Visit poster P018.085D today at 4pm! #eshg2025
May 26, 2025 at 8:03 AM
Group poster today from @jaredgm.bsky.social on genetics of perinatal depression. Jared is a DepGenAfrica postdoc - he is looking for collaborators with African PND data also. Visit poster P018.085D today at 4pm! #eshg2025
Group poster at 13:00 today: Natasha Ali has been investigating rare variants in severe familial anorexia nervosa within the @genomicsengland.bsky.social Genomics England research environment. Visit poster P11.080.C to learn more!
May 26, 2025 at 8:00 AM
Group poster at 13:00 today: Natasha Ali has been investigating rare variants in severe familial anorexia nervosa within the @genomicsengland.bsky.social Genomics England research environment. Visit poster P11.080.C to learn more!
Group poster today - superstar postdoc @rujiawang.bsky.social will present a predictive model for anxiety disorders and their severity in GLAD and UK Biobank-integrating family history, polygenic risk, childhood trauma, and demographics. Poster P11.084.C, 26/5 from 13:00.
May 26, 2025 at 7:54 AM
Group poster today - superstar postdoc @rujiawang.bsky.social will present a predictive model for anxiety disorders and their severity in GLAD and UK Biobank-integrating family history, polygenic risk, childhood trauma, and demographics. Poster P11.084.C, 26/5 from 13:00.
Final day (for me) of #eshg2025. I will be talking on using social media for communication and research at 14.15 - where, according to the agenda, I will have to impersonate @doctorveera.bsky.social!
May 26, 2025 at 7:49 AM
Final day (for me) of #eshg2025. I will be talking on using social media for communication and research at 14.15 - where, according to the agenda, I will have to impersonate @doctorveera.bsky.social!
Group photo from #eshg2025 @jaredgm.bsky.social @rujiawang.bsky.social @johanzvrskovec.bsky.social Natasha Ali, Giuseppe Merola, Ivan Petukhov
May 26, 2025 at 7:32 AM
Group photo from #eshg2025 @jaredgm.bsky.social @rujiawang.bsky.social @johanzvrskovec.bsky.social Natasha Ali, Giuseppe Merola, Ivan Petukhov
Giuseppe Merola, incoming @ukri.org MRC Clinical Research Training Fellow with me at @kingscollegelondon.bsky.social will present on genomic structural equation modeling to isolate mania’s unique genetic architecture in bipolar disorder. P11.091.B at 16:00 today #ESHG2025
May 25, 2025 at 10:27 AM
Giuseppe Merola, incoming @ukri.org MRC Clinical Research Training Fellow with me at @kingscollegelondon.bsky.social will present on genomic structural equation modeling to isolate mania’s unique genetic architecture in bipolar disorder. P11.091.B at 16:00 today #ESHG2025
#eshg2025 @johanzvrskovec.bsky.social from my will present on A comparison of the phenotypic and genetic factor structures across normal and maladaptive personality, measured by HEXACO and PID-5 in the GLAD+ sample (N>14,000). Poster P18.058.A, 25/5 from 13.00.
May 25, 2025 at 10:20 AM
#eshg2025 @johanzvrskovec.bsky.social from my will present on A comparison of the phenotypic and genetic factor structures across normal and maladaptive personality, measured by HEXACO and PID-5 in the GLAD+ sample (N>14,000). Poster P18.058.A, 25/5 from 13.00.
#eshg2025 neuropsych session: Cao Liao covers BioEx and SCHEMA CNVs and SNV work. This is uncovering rare var architecture for bipolar and schizophrenia. Non coding constrained region deletions and duplication emerge as a key set of risk factors.
May 25, 2025 at 9:04 AM
#eshg2025 neuropsych session: Cao Liao covers BioEx and SCHEMA CNVs and SNV work. This is uncovering rare var architecture for bipolar and schizophrenia. Non coding constrained region deletions and duplication emerge as a key set of risk factors.
Krauss Summary - data suggests that older (>50K years) modern human samples misdated it branches that died out as neandethal admix event now shown to be 50k years ago and that DNA is present in all modern humans. #eshg2025
May 24, 2025 at 2:05 PM
Krauss Summary - data suggests that older (>50K years) modern human samples misdated it branches that died out as neandethal admix event now shown to be 50k years ago and that DNA is present in all modern humans. #eshg2025
Krauss: all early modern humans in Europe dark skin, dark hair. Theory is that fair evolved in response to agriculture and low vitamin D much later 11-12k years ago. #eshg2025
May 24, 2025 at 2:05 PM
Krauss: all early modern humans in Europe dark skin, dark hair. Theory is that fair evolved in response to agriculture and low vitamin D much later 11-12k years ago. #eshg2025
Karina Miga @humanpangenome.bsky.social announcing release 2 - each genome is 2 Pacbio flowcells, 2.5 @nanoporetech.com flowcells, 60x omni-c Illumina and hifasm and verkko assemblies of these. #eshg2025 - goal here to have a reference genome that reflects human population.
May 24, 2025 at 12:51 PM
Karina Miga @humanpangenome.bsky.social announcing release 2 - each genome is 2 Pacbio flowcells, 2.5 @nanoporetech.com flowcells, 60x omni-c Illumina and hifasm and verkko assemblies of these. #eshg2025 - goal here to have a reference genome that reflects human population.
Superb to meet @omicsomics.bsky.social at the #nanporeconf today!
May 21, 2025 at 9:50 PM
Superb to meet @omicsomics.bsky.social at the #nanporeconf today!
The all important @nanoporetech.com timeline for this year #nanoporeconf
May 21, 2025 at 6:42 PM
The all important @nanoporetech.com timeline for this year #nanoporeconf
SienaQUANT antibody enrichment to get rid of highly abundant proteins with internal standards to allow quantification (including stoichiometric flattening) #nanoporeconf
May 21, 2025 at 6:30 PM
SienaQUANT antibody enrichment to get rid of highly abundant proteins with internal standards to allow quantification (including stoichiometric flattening) #nanoporeconf
New nanopores for proteins as alternative to indirect antibody and aptamer analyses #nanoporeconf specifically peptide threading method using DNA flanks and DNA motor - cool video not shown.
May 21, 2025 at 6:26 PM
New nanopores for proteins as alternative to indirect antibody and aptamer analyses #nanoporeconf specifically peptide threading method using DNA flanks and DNA motor - cool video not shown.
More than 100M different proteins (including isoforms) #nanoporeconf do @nanoporetech.com have a solution?
May 21, 2025 at 6:22 PM
More than 100M different proteins (including isoforms) #nanoporeconf do @nanoporetech.com have a solution?
Also improved performance for RNA modification and new mods! #nanoporeconf
May 21, 2025 at 6:14 PM
Also improved performance for RNA modification and new mods! #nanoporeconf
Now realising 24 barcodes for direct RNA sequencing - a much desired product! #nanoporeconf
May 21, 2025 at 6:11 PM
Now realising 24 barcodes for direct RNA sequencing - a much desired product! #nanoporeconf