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Reposted
Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestinal epithelial cells, targeting Rab7+ vesicles, altering lipid metabolism, and modulating anti-helminth immunity, revealing a non-pyroptotic function of GsdmC in mucosal immune regulation.
dlvr.it
July 22, 2025 at 2:48 PM
Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity