To try our wake up prediction algorithm today, just search for Propofol Dreams in the app store on your phone. Free for the world forever!

propofoldreams.org

Reference doi:
10.1016/j.bja.2025.01.007

As a pilot study, we validated our novel prediction algorithm in 2 small cohorts of patients: painful and non-painful surgeries (defined as whether additional analgesics were required in PACU). The predictive value of the algorithm was excellent, esp in the No Pain group. 7/7

EXPERIMENT: we tested our hypothesis by examining a simplified cohort of patients where external stimuli (pain, verbal, tactile) at the time of emergence were minimised.
We built a hybrid regression model that predicts the awakening Cp for from maintenance Cp and SE. 6/7

HYPOTHESIS: if we solve for the sigmoid Emax model parameters using maintenance phase data (propofol concentration, state entropy) for a given patient, we may then be able to use these to predict their individualised awakening propofol concentration 5/7

LEMMA: the sigmoid Emax model relates propofol concentration to its pharmacodynamic effect. 3/7

When do you switch off propofol #TCI at the end of a case? How do you predict when the patient will spontaneous eye open and emerge from general anaesthesia?
We tackled this Q in our latest study published in BJA. Here's a quick summary ... 1/7 #AnSky #TIVASky

Yes!!! 😂😂 how did I forget one of our national icons "Bluey"?

Out of curiosity, was the increase in high freq sudden or gradual?
How do you think the table and BIS came in electrical contact?

I had a similar case too where the state entropy gradually increased over 1-2 min (but retained underlying delta).

Turns out to be vibrations from air warmer on cable🤦🏻‍♂️🤦🏻‍♂️

Step 1. Enter your little patient's age, sex, height and weight into the freely available Propofol Dreams app (5F, 21kg, 110cm in this example)

Step 2. Enter the calculated adjusted body weight into the Marsh model (31 kg in this example)

Voila! Marsh model now behaves like paediatric Eleveld! 2/4

Here's a case report of EleMarsh being used for a patient with BMI 57.1

Green dash = Marsh CpT
Red line = Eleveld Ce

Excellent agreement! 3/4

doi.org/10.1177/0310057X241275122

Introducing the EleMarsh algorithm!

All you need to do is enter patient details into our free App, Propofol Dreams. It will calculate the Adjusted Body Weight, and you use that with the Marsh model

Voila, Marsh now behaves identical to Eleveld! 2/4