Katelin Hubbard
@precisionwellness.bsky.social
PhD Biomedical Nutrition. Working in bioinformatics, human metabolism, and metabolic rerouting.
Methanol is converted to the very toxic formate by ADH and ALDH in the liver. Formate inhibits mito Complex IV causing cellular hypoxia and acidosis. ALDH is the critical step and ethanol/Fomepizole are competitive inhibitors of ALDH, preventing it from acting on MeOH, allowing its renal excretion.
November 28, 2024 at 11:10 PM
Methanol is converted to the very toxic formate by ADH and ALDH in the liver. Formate inhibits mito Complex IV causing cellular hypoxia and acidosis. ALDH is the critical step and ethanol/Fomepizole are competitive inhibitors of ALDH, preventing it from acting on MeOH, allowing its renal excretion.