A heartfelt thank you to @lopesaguiarlab.bsky.social , Débora Masini, Beatriz Schweizer and Clara Gomes

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#Neuroscience #Parkinsons #Neurodegeneration #Science

5/ Addressing these issues will push the field toward a more cohesive and impactful understanding of PD—ultimately improving future treatments.

4/ We need to balance model diversity with reproducibility. While new approaches are valuable, replicating and expanding on validated methods is crucial for solid scientific progress.

3/ A major issue: from these 135 articles, we identified 125 unique 6-OHDA models, but only 12 were replicated between articles. This extreme variability limits the reliability of findings in PD research.

2/ Differences in lesion protocols, timing of analyses, and outcome assessments make it difficult to compare studies

1/ In our review, we analyzed 135 studies using 6-OHDA models to investigate non-motor symptoms, following PRISMA guidelines for systematic reviews.