We also found that the malaria response was dominated by type 1 regulatory T (Tr1) cells. These cells expanded with each malaria infection and kept their unique identity over time. Our findings shed light on malaria immunity, and how immune memory works more broadly. Congrats Jason!

We found that the same T-cell clones could persist in blood for hundreds of days and re-expand when a child got malaria again. Although we’ve long known immune memory exists, this was one of the first times it’s been shown so clearly in humans.