“By identifying the proteins that are elevated in affected patients, we’re creating a platform from which to develop diagnostic tools and new targeted therapies,” Dr. Buggert says. “This is especially important since there are no specific biomarkers and treatments for long COVID.”

Using advanced techniques, the researchers out of the Karolinska Institute and Cardiff University measured thousands of proteins in the blood plasma, which they related to the patients’ symptoms. They also used flow cytometry to conduct immunological analyses. polybio.org/polybio-supp...

6/ This has implications for Alzheimer’s & other diseases tied to persistent viral/bacterial infections.

5/ allowing for extremely high resolution images of spike protein in tissue to be produced. If the project team can successfully image SARS-CoV-2 reservoirs in patients with long COVID, they can potentially radiolabel therapeutics that target other pathogens implicated in chronic disease.

4/ In the UCSF project, the EXPLORER PET scanner used in this study is the first FDA-approved full-body PET scanner & was created by two members of the project team. It has 40x the sensitivity of commercial scanners,

3/ It will be great to compare findings between the two imaging teams as both projects continue to move forward.

2/ This PolyBio-supported project at UCSF is working to develop similar imaging methods. The goal is to detect spike protein associated with SARS-CoV-2 reservoirs throughout the body & brains of long COVID patients: polybio.org/projects/use...

3/ Dr. Chan’s talk was a part of PolyBio’s Fall 2024 symposium. Watch the full presentation here (3:34:07): youtu.be/nzwH556GsuU?...

2/ PolyBio is supporting this project that will determine if SCV2 infection of human brain cell models changes protein/gene expression, leading to AD and Parkinson’s. The team will measure how coinfection with HSV1 exacerbates neurodegenerative disease.

4/ Read the full study summary here: polybio.org/projects/cov...

3/ 🦠What is the prevalence of persistent tissue SCV2 in deaths supposedly unrelated to COVID-19?
🦠What are the transcriptional/proteomic host responses in various tissue regions & cell types in acute vs. convalescent COVID-19, & how do these responses correlate with potential SARS-CoV-2 persistence?

2/ The project is expanding the PolyBio-supported POstmortemSystematic InvesTigation of Sudden Cardiac Death autopsy study to examine key questions regarding Long COVID:
🦠What’s the tissue distribution and burden of SCV2 RNA/proteins in tissues of sudden death victims with and without Long Covid?

3/ This presentation was a part of PolyBio’s Fall 2024 Symposium, available here: youtu.be/nzwH556GsuU?...

2/ Supported by PolyBio, Dr. Price & colleagues will analyze lung tissue & blood samples by cutting-edge methods for immune cell activity and SCV2 proteins & viral persistence. The lung microbiome composition is also being characterized & associated with any SCV2 persistence.

3/ This presentation was a part of PolyBio’s Fall 2024 symposium, available here: www.youtube.com/watch?v=nzwH...