A respected clinical academic with 230+ publications and involvement in multiple clinical trials, Prof. Copland is pioneering new treatments for leukaemia.

This project has been generously funded by the Joan Snodgrass PhD studentship, which we are very grateful for!

This is an exciting project that compliments recent successful funding from the NC3Rs.

The project will utilise a novel and fully developed in vitro humanised 3D self-structuring bone model to investigate leukaemic stem cell persistence and behaviour within short-term (<3 months) and long-term (>1 year) culture.

This project will involve validating the bone marrow niche model, testing chemotherapeutic drugs, advanced Brillouin-confocal microscopy and performing biological assays to characterise normal, pre-malignant and malignant samples, working with Professor Helen Wheadon and Professor Mhairi Copland.

This project will focus on cell-to cell interactions and how the architecture of the bone marrow niche is remodelled during malignancy. LSCs dormancy and chemoprotective properties of the bone marrow niche will be areas of interest.

Six clean data plots,
Five grant re-submissions!
Four buffer stocks,
Three PCRs that worked,
Two glowing Westerns,
And a pipette calibrated perfectly!