INOUE, Takeshi
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planarian-brain.bsky.social
INOUE, Takeshi
@planarian-brain.bsky.social
40 followers 55 following 35 posts
プラナリア、脳、定量行動学、環境応答行動、環境適応、再生 /Planarian, Brain, Quantitative Ethology, Environmental response behavior, Environmental Adaptation, and Regeneration
https://www.planarianbrain.com
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INOUE, Takeshi @planarian-brain.bsky.social · Nov 27
Our latest paper entitled "Quantification of planarian behaviors" is published online @dgd_journal. This protocol paper is useful for spatio-temporal analyses of not just planarian behaviors but also for other organisms and cells. #planarian #プラナリア

onlinelibrary.wiley.com/doi/10.1111/...
Quantification of planarian behaviors
Spatiotemporal measurement of individual behaviors offers opportunities to understand complex neural machinery and regeneration of the nervous system in planarians. We describe our step-by-step proto...
onlinelibrary.wiley.com
planarian-brain.bsky.social
ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket | Development | The Company of Biologists
journals.biologists.com/dev/article/...
ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket
Many animals regenerate lost body parts through several signalling pathways; however, the triggers that initiate regeneration remain unclear. In the present study, we focused on the role of reactive o...
journals.biologists.com
November 23, 2025 at 11:03 PM
planarian-brain.bsky.social
Identification of an innexin required for termination of the asexual state in planarian reproductive switching | PLOS Genetics
journals.plos.org/plosgenetics...
Identification of an innexin required for termination of the asexual state in planarian reproductive switching
Author summary Some animals have pluripotent stem cells that can differentiate into all types of cells that make up their adult bodies. Thus, they can regenerate after self-amputation and reproduce as...
journals.plos.org
November 23, 2025 at 11:00 PM
planarian-brain.bsky.social
Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation - ScienceDirect
www.sciencedirect.com/science/arti...
Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation
Development of alternative methods for analysis of reproductive toxicity is a challenge that requires the characterization of mechanistic endpoints li…
www.sciencedirect.com
October 28, 2025 at 9:29 PM
planarian-brain.bsky.social
egal-1 and microtubules promote regeneration polarity in planarians | Development | The Company of Biologists
journals.biologists.com/dev/article/...
egal-1 and microtubules promote regeneration polarity in planarians
Summary: The planarian head-tail regeneration choice requires selective activation of Wnt-inhibitory notum at anterior-facing wounds, a polarized process that requires an Egalitarian-like protein and ...
journals.biologists.com
October 19, 2025 at 5:47 AM
planarian-brain.bsky.social
Paper out! Collaborative decoding of the Iberian ribbed newt genome in iScience

The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians: iScience

www.cell.com/iscience/ful...
The inbred newt genome unveils molecular mechanisms of behavior, development, and regeneration in urodele amphibians
Zoology; Phylogenetics; Evolutionary biology; Phylogeny
www.cell.com
September 25, 2025 at 8:49 AM
planarian-brain.bsky.social
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
www.biorxiv.org/content/10.1...
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense
Current understanding of cytotoxic immunity is shaped by hematopoietic-derived cells -- T cells, natural killer cells, and neutrophils. Here, we identify 'ruptoblasts', a previously unknown cytotoxic ...
www.biorxiv.org
September 18, 2025 at 9:03 PM
planarian-brain.bsky.social
SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians | bioRxiv
www.biorxiv.org/content/10.1...
SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians
Understanding how adult stem cells generate neurons is critical for advancing regenerative medicine. However, few in vivo models enable studying how stem cell fates are specified as neurons in an adul...
www.biorxiv.org
September 2, 2025 at 9:41 PM
planarian-brain.bsky.social
Genetic and Genomic Insights into Planarian Biology | Annual Reviews
www.annualreviews.org/content/jour...
Genetic and Genomic Insights into Planarian Biology | Annual Reviews
Species such as planarians expand our horizons of imagination and fuel innovation. The ability to regenerate any tissues lost to injury has fascinated many generations of biologists studying regenerat...
www.annualreviews.org
August 23, 2025 at 1:34 PM
planarian-brain.bsky.social
Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl - Hayashi - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....
Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl
Cell tracing is an essential method for deciphering cellular processes during organ regeneration. We generated transgenic Iberian ribbed newts carrying the multicolor reporter Brainbow3.0 cassette un...
onlinelibrary.wiley.com
August 11, 2025 at 9:09 AM
planarian-brain.bsky.social
「プラナリアの体が宿した"記憶"」
少しだけコメントさせていただきました。
www.nikkei-science.com/page/magazin...
2025年8月号｜日経サイエンス
天体物理学 特集：認知の原点を探る 人工知能がこれだけ発展しても，私たちはまだ自らの知能についてよく理解できていない。プラナリアの脳再生や動植物の賢い振る舞い，AIとロボットの関係など多様な視点から生物の認知機能を見つめ … 続きを読む →
www.nikkei-science.com
June 19, 2025 at 2:10 AM
planarian-brain.bsky.social
Step‐by‐Step Protocol for Making a Knock‐In Xenopus laevis to Visualize Endogenous Gene Expression - Kagawa - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
June 14, 2025 at 12:13 PM
planarian-brain.bsky.social
our paper is out!

Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs - ScienceDirect
www.sciencedirect.com/science/arti...
Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs
Previous studies suggested the importance of the reciprocal interactions between residual tissues, which we refer to here as the “stump”, and the newl…
www.sciencedirect.com
June 11, 2025 at 11:02 PM
planarian-brain.bsky.social
Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea | bioRxiv
www.biorxiv.org/content/10.1...
Contributions of m6A RNA methylation to germline development in the planarian Schmidtea mediterranea
N6-methyladenosine (m6A) is one of the most prevalent post-transcriptional modifications of eukaryotic RNA molecules. This post-transcriptional modification is essential in biological contexts ranging...
www.biorxiv.org
June 6, 2025 at 3:18 AM
planarian-brain.bsky.social
A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen | BMC Genomics
bmcgenomics.biomedcentral.com/articles/10....
A Mg2+-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen - BMC Genomics
Background The isolation of intact, high-molecular-weight genomic DNA (HMW gDNA) is essential for achieving complete genome assemblies. However, extracting HMW gDNA from a single individual of Dugesia...
bmcgenomics.biomedcentral.com
May 29, 2025 at 1:30 AM
planarian-brain.bsky.social
Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons | bioRxiv
www.biorxiv.org/content/10.1...
Combinatorial mechanisms specify cellular location and neurotransmitter identity during regeneration of planarian neurons
During regenerative neurogenesis, neurons must be created in the right types and locations. Though regenerative neurogenesis is limited in humans, other animals use regenerative neurogenesis to faithf...
www.biorxiv.org
May 26, 2025 at 12:59 PM
planarian-brain.bsky.social
Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians | bioRxiv
www.biorxiv.org/content/10.1...
Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians
POU4 homologs are involved in the development of sensory cell types across diverse species, including cnidarians, ascidians, and mammals. Whether these developmental regulators are reused during adult...
www.biorxiv.org
May 16, 2025 at 2:32 PM
planarian-brain.bsky.social
Frontiers | Planarian RNAi knockdown: feeding once might just be enough
www.frontiersin.orghttps//www.frontie...
www.frontiersin.orghttps
April 21, 2025 at 7:05 AM
planarian-brain.bsky.social
Developmental onset of planarian whole-body regeneration depends on axis reset: Current Biology
www.cell.com/current-biol...
Developmental onset of planarian whole-body regeneration depends on axis reset
Booth et al. show that the planarian Schmidtea polychroa gradually gains its impressive regenerative abilities during development. While regeneration involves many factors, this study shows that the r...
www.cell.com
April 18, 2025 at 12:30 PM
planarian-brain.bsky.social
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants - Sato - 2025 - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10....
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants
Some transcription factors exhibit chromosomal localization during M-phase and play an important role in the rapid re-activation of target genes in early G1-phase. In this study, we assessed the chro...
onlinelibrary.wiley.com
April 16, 2025 at 12:07 PM
planarian-brain.bsky.social
Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging
www.nature.com/articles/s43...
Regeneration leads to global tissue rejuvenation in aging sexual planarians - Nature Aging
The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immort...
www.nature.com
April 4, 2025 at 2:03 PM
planarian-brain.bsky.social
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense | bioRxiv
www.biorxiv.org/content/10.1...
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense
Cytotoxic killing is an essential immune function, yet its cellular mechanisms have been characterized in only a few model species. Here, we show that planarian flatworms harness a unique cytotoxic st...
www.biorxiv.org
April 2, 2025 at 10:05 PM
planarian-brain.bsky.social
Temporal integration and active sensing of light in planarians | bioRxiv
www.biorxiv.org/content/10.1...
Temporal integration and active sensing of light in planarians
Animal light sensing and processing are intimately connected to the design of the sensory apparatus, with eye-design a subject of longstanding interest. Understanding animal response to stimuli can el...
www.biorxiv.org
March 30, 2025 at 11:38 PM
planarian-brain.bsky.social
Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells | BMC Genomics |
bmcgenomics.biomedcentral.com/articles/10....
Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells - BMC Genomics
Background The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types...
bmcgenomics.biomedcentral.com
March 13, 2025 at 9:04 AM
planarian-brain.bsky.social
Keratinocyte-driven dermal collagen formation in the axolotl skin | Nature Communications
www.nature.com/articles/s41...
Keratinocyte-driven dermal collagen formation in the axolotl skin - Nature Communications
Type I collagen in the dermis is a major component of the skin, though how this collagen is formed and modified as remained unclear. Here they show that keratinocytes contribute to dermal collagen for...
www.nature.com
February 24, 2025 at 10:39 PM
planarian-brain.bsky.social
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants - Sato - Development, Growth & Differentiation - Wiley Online Library
onlinelibrary.wiley.com/doi/abs/10.1...
Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants
Some transcription factors exhibit chromosomal localization during M-phase and play an important role in the rapid re-activation of target genes in early G1-phase. In this study, we assessed the chro....
onlinelibrary.wiley.com
February 12, 2025 at 8:38 AM