Pauliina Kallio
@pkalliomdphd.bsky.social
Just published in Cancer Research!
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...
A Multipotent PROX1+ Tumor Stem/Progenitor Cell Population Emerges during Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer
Colorectal cancer stem/progenitor cells expressing the PROX1 transcription factor display increased radiation resistance, which may be targeted by small-molecule inhibitors of the nonhomologous end-jo...
doi.org
December 12, 2025 at 4:58 PM
Just published in Cancer Research!
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...
We show that PROX1+ colorectal cancer stem cells drive therapy resistance: they self-renew, survive irradiation via enhanced DNA damage repair, and could be targeted with NHEJ inhibitors.
Check out details: doi.org/10.1158/0008...