Brilliant teamwork from colleagues at IARCWHO, @sangerinstitute.bsky.social and UCSD, esp first authors mdiazgay, wellington dos Santos and drsarahmoody, Ludmil and Mike, + partners from 11 countries, as well as great support from the CancerGrand Challenges. @cancergrand.bsky.social

Mutational signatures linked to colibactin were over 3 times more common among individuals diagnosed before age 40 than in those over 70, and were imprinted early during colorectal cancer development. Raises question of whether this is cause of increase in incidence of eoCRC.