Thank you, Jeremy!

Thanks Giulia! I'm looking forward to watching your talk when it's put on the meeting app!

Unfortunately, due to a last minute family medical issue, I will not be able to attend in person but will give my talk virtually and am available on here or via email to discuss our work after!

As a PI during these tough financial times, we really appreciate societies like @theaacr.bsky.social for supporting our trainees to attend conferences that are critical for their growth!

🙏 Thank you @AACR_CEO Margaret Foti!

Congrats Cosimo!!

Immensely grateful to all collaborators from the Guertin, @marcus-ruscetti.bsky.social, @game-of-chroms.bsky.social, Zhu, Kremer, Czech, Guilherme, and Hollingsworth labs. you all have made this journey an amazing one.🙏

Most importantly, this paper only came together because of the fantastic community of collaborators we have built over the years.

Really proud of my team led by @nikitab.bsky.social with critical support from Yamini Ogoti, @jessicapeura.bsky.social, and @calvinjohnsonio.bsky.social

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To wrap this story up, we treated KPCY animals with a monoclonal neutralizing antibody against PTHrP (🙏 Richard Kremer), which was able to block wasting and restore DNL. We are hoping this will be a new therapeutic option for patients suffering from cancer cachexia in the near future

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This is where we relied on our adipose tissue expert collaborators (Dave Guertin, Mike Czech, Adilson Guilherme labs), who helped us delete Fasn, a key enzyme in the DNL pathway, in adipocytes. When we injected a non-cachectic cell line into these mice, we found that it became cachectic!

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To figure out how PTHrP mediates adipose tissue wasting, we performed RNA-seq on cachectic iWAT and found the usual players being upregulated (TNF, IL6, etc.), but were surprised to also see a dramatic downregulation of de novo lipogenesis (DNL) in the adipose of cachectic mice

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