Giuseppina lambiase
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pina85.bsky.social
Giuseppina lambiase
@pina85.bsky.social
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pina85.bsky.social
Thank you very much for the support !
May 3, 2025 at 3:42 PM
pina85.bsky.social
Thank you Laura!
May 2, 2025 at 3:16 PM
pina85.bsky.social
Functionally, we demostrated that transition from CV to IVC represents a shift from a multifunctional embryonic vein to a specialized adult conduit adapted for high-volume blood return.
Here one of the functional divergence between CV and IVC. Rhodamine Dextran 10KDA is internalized by the embryonic cardinal vein ( fig. I, yellow arrowheads) but not by the IVC (fig.J) indicating that IVC lack the scavenger function characteristic of their CV counterparts!
May 2, 2025 at 2:54 PM
pina85.bsky.social
We found that this vein-to-vein process is regulated by vegfa/flt1/dll4 axis.
This panel shows a malformed IVC when vegfa is mutated
May 2, 2025 at 2:32 PM
pina85.bsky.social
Using lineare tracing tool we demostrated that IVC arise only from the venous source with no contribution of the #Artery or #lymphatic
In this panel, “flibow” tool was used to study the cellular original of the inferior Vena Cava. Venous sprouts from the cardinal vein ( fig. D, magenta arrowhead) give rise to the Inferior Vena Cava (fig. F, magenta arrowhead) .
May 2, 2025 at 2:23 PM