Pierre Le Merre
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pierrelemerre.bsky.social
Pierre Le Merre
@pierrelemerre.bsky.social
CNRS Researcher at CRNL. Research Specialist at Karolinska Institutet, Stockholm. Studying the prefrontal cortex and cognition in rodents. Electronic musician.

lab : https://www.lab.pierrelemerre.com/
personal webpage: https://www.pierrelemerre.com/
Cool I don’t this one! I will check it out thanks.
September 6, 2025 at 10:48 PM
But …fine grained connectivity seems to have little to do with cytoarchitecture (see Gou et al 2025).
September 6, 2025 at 9:08 PM
Reposted by Pierre Le Merre
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September 3, 2025 at 4:22 PM
This has been a blast! Such a treat to be hosted by @hhmijanelia.bsky.social at this workshop by organized by @nwb.org! Re-analysis of open-data form @dandiarchive.org with so many talented scientists has been so much fun!
July 20, 2025 at 10:07 AM
(Really cool thread by the way!!)
July 8, 2025 at 8:56 AM
It feels like you are onto something (need to read your book)! The field needs theories and models to be put out there, to be tested, and be dropped or propagated. What we refer to as emotions can be put into math the same way we deal with other brain « functions ». We will learn from this process!
July 8, 2025 at 8:55 AM
Yes! I was mainly curious about spike interface.
June 16, 2025 at 5:47 PM
Thanks for sharing this toolbox! What is the required input data format? Any sorter will do or does it need to be Kilosort?
June 15, 2025 at 9:22 PM
Mice also squint more over the time course of the repeated air puffs. That could be the « state » that we track down with single unit activity…..
June 1, 2025 at 5:51 PM
Interesting. We observed similar shift of inter-trial activity between air puffs in a previous study: www.nature.com/articles/s41.... No humans and no Ketamine in there, only mice. But we can trigger the same shift with subcortical stimulation (hypothalamus/habenula projection).
Esr1+ hypothalamic-habenula neurons shape aversive states - Nature Neuroscience
The authors find a surprising diversity in hypothalamic neurons projecting to habenula, and using patch-sequencing (Patch-seq), identify an estrogen receptor-expressing neuron type that signals aversi...
www.nature.com
June 1, 2025 at 5:48 PM
The suggested experiments were also incredibly naive and simplistic to me…. I.e. if region A lights up theory A is true, else if region B lights up B is true….like really?
May 20, 2025 at 11:55 AM
Interesting indeed! So we loose the retinotopy as we go frontal. I wonder why is it so « slow »… Do we see here network activations (i.e. polysynaptic) in Frontal regions following monosynaptic input?
March 27, 2025 at 7:13 PM
Interesting Sunday Morning read!Very nice conceptual tour on the notion of causation in Neuroscience
March 16, 2025 at 9:49 AM