Piergiorgio Castioni
@piercastioni.bsky.social
PhD candidate at Universitat Rovira i Virgili, Tarragona, Spain. Started from Statistical Physics, now I'm into Infectious Disease Modeling.
My life is a continuous struggle to balance fiction and non-fiction in my library 📚
My life is a continuous struggle to balance fiction and non-fiction in my library 📚
I am very proud of this work and I hope I will have time to expand on it in the future. There is still so much to do!
But for now, thank you for reading ✌️
journals.aps.org/pre/abstract...
But for now, thank you for reading ✌️
journals.aps.org/pre/abstract...
Network-driven vaccination strategies for preventing rebound dynamics in metapopulation epidemic control
A critical question in epidemic control concerns the minimal requirements for a vaccination campaign to effectively halt a contagion process. However, control measures can inadvertently trigger resurg...
journals.aps.org
July 22, 2025 at 10:54 AM
I am very proud of this work and I hope I will have time to expand on it in the future. There is still so much to do!
But for now, thank you for reading ✌️
journals.aps.org/pre/abstract...
But for now, thank you for reading ✌️
journals.aps.org/pre/abstract...
The solution? Avoid the generalized growth of susceptible population throughout the network by dividing it in sectors and vaccinate each of them asynchronously.
July 22, 2025 at 10:54 AM
The solution? Avoid the generalized growth of susceptible population throughout the network by dividing it in sectors and vaccinate each of them asynchronously.
We found that there is a single parameter, the reduced R0, that controls the whole dynamics and is the best predictor of whether there is going to be a rebound or not. This quantity tells us if the vaccination campaign only affects the targeted patched or if it has a global effect on the network.
July 22, 2025 at 10:54 AM
We found that there is a single parameter, the reduced R0, that controls the whole dynamics and is the best predictor of whether there is going to be a rebound or not. This quantity tells us if the vaccination campaign only affects the targeted patched or if it has a global effect on the network.
Now with this new paper we turn to the question of how the geographical distribution of vaccines influences this rebound.
July 22, 2025 at 10:54 AM
Now with this new paper we turn to the question of how the geographical distribution of vaccines influences this rebound.
Interestingly enough this population-level effect mirrors the "viral rebound" that is occasionally seen at the host level, when people supposedly healed by antiviral medications suddenly start showing symptoms again. But I digress...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A unifying model to explain frequent SARS-CoV-2 rebound after nirmatrelvir treatment and limited prophylactic efficacy - Nature Communications
Viral rebound has been observed following treatment with Paxlovid. Here the authors develop a mathematical model for viral-immune dynamics and nirmatrelvir pharmacokinetics and suggest that early trea...
www.nature.com
July 22, 2025 at 10:54 AM
Interestingly enough this population-level effect mirrors the "viral rebound" that is occasionally seen at the host level, when people supposedly healed by antiviral medications suddenly start showing symptoms again. But I digress...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In a previous paper we had found that a badly timed vaccination campaign can lead to immediate benefits but also to large build-up of susceptibles which can fuel later resurgencies, called "rebounds".
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Rebound in epidemic control: how misaligned vaccination timing amplifies infection peaks - npj Complexity
npj Complexity - Rebound in epidemic control: how misaligned vaccination timing amplifies infection peaks
www.nature.com
July 22, 2025 at 10:54 AM
In a previous paper we had found that a badly timed vaccination campaign can lead to immediate benefits but also to large build-up of susceptibles which can fuel later resurgencies, called "rebounds".
www.nature.com/articles/s44...
www.nature.com/articles/s44...