Michael Sewell
@pichaelmichael.bsky.social
🇬🇧 🇦🇺 🇮🇪 Postdoc, Goate Lab @ Icahn School of Medicine at Mount Sinai, New York. Interested in microglia, 🧬, Alzheimer’s and all things omics (and Formula 1!). Previously @ University of Edinburgh, Montagne Lab
Reposted by Michael Sewell
Very VERY proud to have been part of this incredible piece of work
Hundreds of paired and group interactions, exploring the double empathy problem in a large diverse sample.
Hundreds of paired and group interactions, exploring the double empathy problem in a large diverse sample.
New paper alert!
Information transfer within and between autistic and non-autistic people is out today in @nathumbehav.nature.com
nature.com/articles/s41...
THREAD! 🧵⬇️
Information transfer within and between autistic and non-autistic people is out today in @nathumbehav.nature.com
nature.com/articles/s41...
THREAD! 🧵⬇️
May 14, 2025 at 8:03 PM
Very VERY proud to have been part of this incredible piece of work
Hundreds of paired and group interactions, exploring the double empathy problem in a large diverse sample.
Hundreds of paired and group interactions, exploring the double empathy problem in a large diverse sample.
good to see work that really cares about statistical rigor too in the field (something that is really lacking) - awesome job!
Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...
rdcu.be
April 30, 2025 at 5:36 PM
good to see work that really cares about statistical rigor too in the field (something that is really lacking) - awesome job!
Reposted by Michael Sewell
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 18, 2025 at 11:27 PM
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
Reposted by Michael Sewell
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 5:47 PM
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Reposted by Michael Sewell
Friendly reminder: if you are waiting on something from a US-based scientist/reviewer/editor, please realize that we're barely making it through each day putting out non-stop fires and trying not to collapse into tears. We're trying our best, but things will take longer right now. Give grace.
March 3, 2025 at 7:22 PM
Friendly reminder: if you are waiting on something from a US-based scientist/reviewer/editor, please realize that we're barely making it through each day putting out non-stop fires and trying not to collapse into tears. We're trying our best, but things will take longer right now. Give grace.
2025 off to a decent start...Happy to share my latest first author paper with the brilliant Nela Fialova and @axelmontagne.bsky.social where we sought to identify genes that are frequently altered in vascular cells in CNS disorders across existing datasets. Check it out here!
🚨 Latest contribution where we delve into the dementia-related snRNAseq data & spotlight the signature changes in #endothelialcells and #pericytes!
Proud of the effort led by Dr. Michael Sewell @pichaelmichael.bsky.social and Nela Fialova.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Proud of the effort led by Dr. Michael Sewell @pichaelmichael.bsky.social and Nela Fialova.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Unraveling the transcriptomic landscape of brain vascular cells in dementia: A systematic review
INTRODUCTION Cerebrovascular dysfunction plays a critical role in the pathogenesis of dementia and related neurodegenerative disorders. Recent omics-driven research has revealed associations between...
alz-journals.onlinelibrary.wiley.com
January 14, 2025 at 12:01 PM
2025 off to a decent start...Happy to share my latest first author paper with the brilliant Nela Fialova and @axelmontagne.bsky.social where we sought to identify genes that are frequently altered in vascular cells in CNS disorders across existing datasets. Check it out here!
Work from my undergrad (over eight years ago now 🤣) officially out as a pre-print! Check it out here
Redox-dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells https://www.biorxiv.org/content/10.1101/2024.12.13.628382v1
December 17, 2024 at 2:27 AM
Work from my undergrad (over eight years ago now 🤣) officially out as a pre-print! Check it out here
awesome opportunity with a great bunch of PIs :)
Interested in pursuing a PhD with Dr Ben Dickie, Dr Harry Pritchard, and me to explore the role of mural cells in Alzheimer’s disease?
Feel free to apply or share this opportunity widely!
www.findaphd.com/phds/project...
Feel free to apply or share this opportunity widely!
www.findaphd.com/phds/project...
(VIDA DTC) Role of arterial smooth muscle and pericyte dysfunction towards brain waste clearance in Alzheimer’s Disease at The University of Manchester on FindAPhD.com
PhD Project - (VIDA DTC) Role of arterial smooth muscle and pericyte dysfunction towards brain waste clearance in Alzheimer’s Disease at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
November 25, 2024 at 10:31 PM
awesome opportunity with a great bunch of PIs :)
Reposted by Michael Sewell
PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
(VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh on FindAPhD.com
PhD Project - (VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
November 25, 2024 at 10:21 AM
PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Michael Sewell
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
November 14, 2024 at 3:21 AM
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!