www.nature.com/articles/s41...

✅ The main enriched pathway involved the upregulation of the pro-inflammatory regulator NF-κB2. Chronic stress—whether biological or social—can trigger activation of this pathway. Persistent activation accelerates tissue damage and increases susceptibility to age-related conditions.

✅ Social disadvantage is associated with proteomic signatures of accelerated immune aging
✅ 14 age-related #proteins mediate up to 39% of the link between social disadvantage and age-related diseases
✅ Individuals facing social disadvantage had an increased risk for 66 age-related diseases

Our research has also been featured in the @financialtimes.com www.ft.com/content/9510...

📌 In most cases, ageing of one organ increased susceptibility to diseases in multiple organs.

📌 Plasma-based organ age signatures could provide a quick, non-invasive way to improve disease prediction and prevention.
@uclpsychiatry.bsky.social @helsinki.fi www.ft.com/content/9510...

📌 Faster organ ageing was associated with an increased risk of 30 age-related diseases.

📌 The development of some diseases—such as liver failure, chronic heart failure, and lung cancer—was exclusively associated with accelerated ageing of their respective organ.

Using proteomic data from 6,235 participants of the Whitehall II study , we determined how much an organ's biological age deviates from what’s typically expected for someone of the same age. We then tracked participants for 20 years to examine their risk of developing 45 age-related diseases.